04426nam 22007215 450 991030035790332120200701101735.00-387-75613-210.1007/978-0-387-75613-4(CKB)3710000000072530(EBL)1592836(SSID)ssj0001067454(PQKBManifestationID)11675228(PQKBTitleCode)TC0001067454(PQKBWorkID)11091892(PQKB)11031792(MiAaPQ)EBC1592836(DE-He213)978-0-387-75613-4(PPN)176095489(EXLCZ)99371000000007253020131123d2014 u| 0engur|n|---|||||txtccrFundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics /edited by Alexander A. Vinks, Hartmut Derendorf, Johan W. Mouton1st ed. 2014.New York, NY :Springer New York :Imprint: Springer,2014.1 online resource (467 p.)Description based upon print version of record.0-387-75612-4 Includes bibliographical references and index.Foreword -- Section I: Basic Concepts and Principles -- Introduction to Pharmacodynamics and micrbiology -- In vitro and animal PK/PD model -- MIC and breakpoints -- Principles of applied PK/PD modeling -- Population Pk/PD modeling and its applications to antimicrobials -- Drug resistance and Drug-drug combinations -- Section II: Clinical -- Aminoglycosides -- Beta-lactam antibiotics including continuous infusion -- Macrolides -- Glycopeptides -- Quinolones -- Other.-      .Over the past decade, significant progress has been made in the theory and applications of pharmacodynamics of antimicrobial agents. On the basis of pharmacokinetic-pharmacodynamic modeling concepts it has become possible to describe and predict the time course of antimicrobial effects under normal and pathophysiological conditions. The study of pharmacokinetic-pharmacodynamic relationships can be of considerable value in understanding drug action, defining optimal dosing regimens, and in making predictions under new or changing pre-clinical and clinical circumstances. Not surprisingly, pharmacokinetic-pharmacodynamic modeling concepts are increasingly applied in both basic and clinical research as well as in drug development. Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics  is designed as a reference on the application of pharmacokinetic-pharmacodynamic principles for the optimization of antimicrobial therapy, namely pharmacotherapy, and infectious diseases. The reader is introduced to various aspects of the fundamentals of antimicrobial pharmacodynamics, the integration of pharmacokinetics with pharmacodynamics for all major classes of antibiotics, from basic research to clinical situations.Infectious diseasesPharmacologyImmunologyMedical microbiologyPublic healthInfectious Diseaseshttps://scigraph.springernature.com/ontologies/product-market-codes/H33096Pharmacology/Toxicologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B21007Immunologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B14000Medical Microbiologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B16003Public Healthhttps://scigraph.springernature.com/ontologies/product-market-codes/H27002Infectious diseases.Pharmacology.Immunology.Medical microbiology.Public health.Infectious Diseases.Pharmacology/Toxicology.Immunology.Medical Microbiology.Public Health.615.7Vinks Alexander Aedthttp://id.loc.gov/vocabulary/relators/edtDerendorf Hartmutedthttp://id.loc.gov/vocabulary/relators/edtMouton Johan Wedthttp://id.loc.gov/vocabulary/relators/edtBOOK9910300357903321Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics1523030UNINA