03902nam 22005655 450 991030031830332120200629140542.03-662-56179-410.1007/978-3-662-56179-9(CKB)3840000000347736(MiAaPQ)EBC5287480(DE-He213)978-3-662-56179-9(PPN)224635867(EXLCZ)99384000000034773620180209d2018 u| 0engurcnu||||||||rdacontentrdamediardacarrierCellular Dedifferentiation and Regenerative Medicine /by Xiaobing Fu, Andong Zhao, Tian Hu1st ed. 2018.Berlin, Heidelberg :Springer Berlin Heidelberg :Imprint: Springer,2018.1 online resource (291 pages)3-662-56177-8 Includes bibliographical references at the end of each chapters and index.A brief history of Regeneration -- The origin of cells in Regeneration -- Cell dedifferentiation -- Cell transdifferentiation -- Cell reprogramming -- Dedifferentiation vs Transdifferentiation vs Reprogramming -- The extent of cell dedifferentiation -- Maintenance of cell differentiated identity -- Unstable differentiated state -- Epidermal cell dedifferentiation and skin regeneration -- Peripheral nerve regeneration and Schwann cell dedifferentiation -- Central nervous system and dedifferentiation -- Dedifferentiation and Heart -- Dedifferentiation and Kidney -- Dedifferentiation and other 4 systems -- The relationship between cell dedifferentiation and development of cancer and several diseases.This book focuses on the contribution of cell dedifferentiation to the regenerative process in all body systems, as well as its underlying molecular mechanisms and applications. The book is divided into four parts, the first of which addresses the history of cell dedifferentiation and regenerative medicine. In turn, Part II compares three routes by which cells change their phenotype: dedifferentiation, transdifferentiation, and reprogramming. Part III includes an extensive review of cell dedifferentiation events in all nine body systems for lower organisms and mammalians, respectively. The final part reviews the relationship between cell dedifferentiation and the development of cancer and several other diseases, while also outlining the prospects of and future research directions in cell dedifferentiation and regenerative medicine. The main purpose of the book is to underline the importance of cell dedifferentiation in stem cell and regenerative medicine by providing a systematical review of dedifferentiation in all body systems, together with the latest reliable evidence.TraumatologyDermatologyRegenerative medicineTissue engineeringTraumatic Surgeryhttps://scigraph.springernature.com/ontologies/product-market-codes/H59125Dermatologyhttps://scigraph.springernature.com/ontologies/product-market-codes/H1900XRegenerative Medicine/Tissue Engineeringhttps://scigraph.springernature.com/ontologies/product-market-codes/L16080Traumatology.Dermatology.Regenerative medicine.Tissue engineering.Traumatic Surgery.Dermatology.Regenerative Medicine/Tissue Engineering.571.889Fu Xiaobingauthttp://id.loc.gov/vocabulary/relators/aut782384Zhao Andongauthttp://id.loc.gov/vocabulary/relators/autHu Tianauthttp://id.loc.gov/vocabulary/relators/autBOOK9910300318303321Cellular Dedifferentiation and Regenerative Medicine2065748UNINA