04218nam 22005895 450 991030031320332120200701215025.03-319-64451-310.1007/978-3-319-64451-6(CKB)4100000000882252(DE-He213)978-3-319-64451-6(MiAaPQ)EBC5092597(PPN)220126070(EXLCZ)99410000000088225220171006d2018 u| 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierD-type Cyclins and Cancer[electronic resource] /edited by Philip W. Hinds, Nelson E. Brown1st ed. 2018.Cham :Springer International Publishing :Imprint: Humana,2018.1 online resource (IX, 152 p. 29 illus., 25 illus. in color.) Current Cancer Research,2199-25843-319-64449-1 Includes bibliographical references at the end of each chapters and index.The D-type Cyclins: A Historical Perspective -- Mammalian Development and Cancer – A Brief History of Mice Lacking D-type Cyclins or Cdk4/6 -- D-type Cyclins and Gene Transcription -- Splice Variants and Phosphorylated Isoforms of Cyclin D1 in Tumorigenesis -- Cyclin D1, Metabolism, and the Autophagy-Senescence Balance -- Shifting a Paradigm: Cyclin D Activates pRb by Mono-Phosphorylation.This volume provides an integrated account of our current understanding of the functions of D-type cyclins during development and tumorigenesis, with special emphasis on the kinase-independent functions of these proteins. The volume will provide a thorough review of the latest discoveries on the new functions and interacting partners of mammalian cyclin Ds crucial to explain their oncogenic and differentiation properties in different cellular contexts. The volume begins with a historical perspective of how D-type cyclins were first discovered and eventually cloned from cancer tissues, followed by an account on the canonical functions of cyclin Ds during the G1-S transition of the cell cycle. Several chapters will be devoted to review the functions of D-type cyclins as transcriptional regulators and the mechanisms through which these novel functions could impact the tumorigenic process. Also discussed is emerging evidence that points to a role of D-type cyclins, particularly cyclin D1, as a cytoplasmic regulator of various cellular functions. This property, in human cells at least, is traceable to certain splice isoforms with novel oncogenic implications. Finally, a chapter is devoted to recent efforts to revise the canonical view of the “retinoblastoma pathway” to incorporate new evidence that suggests that cyclin D1’s role in G1 is to singly-phosphorylate the retinoblastoma protein (pRb) for discrimination of target protein interactions. This work represents a significant departure from the view of cyclin D1 as a negative regulator of pRb and may have critical implications for understanding the function of antineoplastic agents that target the cyclin D1-associated kinases.Current Cancer Research,2199-2584Cancer researchCell cycleMolecular biologyCancer Researchhttps://scigraph.springernature.com/ontologies/product-market-codes/B11001Cell Cycle Analysishttps://scigraph.springernature.com/ontologies/product-market-codes/L16030Molecular Medicinehttps://scigraph.springernature.com/ontologies/product-market-codes/B1700XCancer research.Cell cycle.Molecular biology.Cancer Research.Cell Cycle Analysis.Molecular Medicine.616.994071Hinds Philip Wedthttp://id.loc.gov/vocabulary/relators/edtBrown Nelson Eedthttp://id.loc.gov/vocabulary/relators/edtMiAaPQMiAaPQMiAaPQBOOK9910300313203321D-type Cyclins and Cancer1745065UNINA