03685nam 22005775 450 991030030840332120200707020722.03-319-63187-X10.1007/978-3-319-63187-5(CKB)4340000000223279(DE-He213)978-3-319-63187-5(MiAaPQ)EBC5161624(PPN)258852941(PPN)221252304(EXLCZ)99434000000022327920171124d2018 u| 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierChromatin Regulation of Early Embryonic Lineage Specification /edited by Jason Knott, Keith Latham1st ed. 2018.Cham :Springer International Publishing :Imprint: Springer,2018.1 online resource (VII, 78 p. 16 illus. in color.) Advances in Anatomy, Embryology and Cell Biology,0301-5556 ;2293-319-63186-1 Includes bibliographical references at the end of each chapters.CHD1 controls cell lineage specification through zygotic genome activation -- Chromatin remodelling proteins and cell fate decisions in mammalian preimplantation development -- Transcriptional regulation and genes involved in first lineage specification during preimplantation development -- ROCK and RHO playlist for preimplantation development: Streaming to HIPPO pathway and apicobasal polarity in the first cell differentiation -- XEN and the art of stem cell maintenance - molecular mechanisms maintaining cell fate and self-renewal in extraembryonic endoderm stem (XEN) cell lines.  .Five leaders in the field of mammalian preimplantation embryo development provide their own perspectives on key molecular and cellular processes that mediate lineage formation during the first week of life. The first cell-fate decision involves the formation of the pluripotent inner cell mass (ICM) and extraembryonic trophectoderm (TE). The second cell-fate choice encompasses the transformation of ICM into extraembryonic primitive endoderm (PE) and pluripotent epiblast. The processes, which occur during the period of preimplantation development, serve as the foundation for subsequent developmental events such as implantation, placentation, and gastrulation. The mechanisms that regulate them are complex and involve many different factors operating spatially and temporally over several days to modulate embryonic chromatin structure, impose cellular polarity, and direct distinct gene expression programs in the first cell lineages. .Advances in Anatomy, Embryology and Cell Biology,0301-5556 ;229Human geneticsCytologyHuman physiologyHuman Geneticshttps://scigraph.springernature.com/ontologies/product-market-codes/B12008Cell Biologyhttps://scigraph.springernature.com/ontologies/product-market-codes/L16008Human Physiologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B13004Human genetics.Cytology.Human physiology.Human Genetics.Cell Biology.Human Physiology.611.01816599.935Knott Jasonedthttp://id.loc.gov/vocabulary/relators/edtLatham Keithedthttp://id.loc.gov/vocabulary/relators/edtBOOK9910300308403321Chromatin Regulation of Early Embryonic Lineage Specification1743097UNINA