03784nam 2200433z- 450 991013679950332120210211(CKB)3710000000631127(oapen)https://directory.doabooks.org/handle/20.500.12854/52948(oapen)doab52948(EXLCZ)99371000000063112720202102d2015 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMechanisms of neuroinflammation and inflammatory neurodegeneration in acute brain injuryFrontiers Media SA20151 online resource (284 p.)Frontiers Research Topics2-88919-691-7 Mechanisms of brain-immune interactions became a cutting-edge topic in systemic neurosciences over the past years. Acute lesions of the brain parenchyma, particularly, induce a profound and highly complex neuroinflammatory reaction with similar mechanistic properties between differing disease paradigms like ischemic stroke, intracerebral hemorrhage (ICH) and traumatic brain injury (TBI). Resident microglial cells sense tissue damage and initiate inflammation, activation of the endothelial brain-immune interface promotes recruitment of systemic immune cells to the brain and systemic humoral immune mediators (e.g. complements and cytokines) enter the brain through the damaged blood-brain barrier. These cellular and humoral constituents of the neuroinflammatory reaction to brain injury contribute substantially to secondary brain damage and neurodegeneration. Diverse inflammatory cascades such as pro-inflammatory cytokine secretion of invading leukocytes and direct cell-cell-contact cytotoxicity between lymphocytes and neurons have been demonstrated to mediate the inflammatory 'collateral damage' in models of acute brain injury. Besides mediating neuronal cell loss and degeneration, secondary inflammatory mechanisms also contribute to functional modulation of neurons and the impact of post-lesional neuroinflammation can even be detected on the behavioral level. The contribution of several specific immune cell subpopulations to the complex orchestration of secondary neuroinflammation has been revealed just recently. However, the differential vulnerability of specific neuronal cell types and the molecular mechanisms of inflammatory neurodegeneration are still elusive. Furthermore, we are only on the verge of characterizing the control of long-term recovery and neuronal plasticity after brain damage by inflammatory pathways. Yet, a more detailed but also comprehensive understanding of the multifaceted interaction of these two supersystems is of direct translational relevance. Immunotherapeutic strategies currently shift to the center of translational research in acute CNS lesion since all clinical trials investigating direct neuroprotective therapies failed. To advance our knowledge on brain-immune communications after brain damage an interdisciplinary approach covered by cellular neuroscience as well as neuroimmunology, brain imaging and behavioral sciences is crucial to thoroughly depict the intricate mechanisms.NeurosciencesbicsscCytokinesImmunityintracerebral hemorrhageLeukocytesneurodegenerationNeuroinflammationStrokeTraumatic Brain InjuryNeurosciencesArthur Lieszauth1278632Christoph KleinschnitzauthBOOK9910136799503321Mechanisms of neuroinflammation and inflammatory neurodegeneration in acute brain injury3013628UNINA04676nam 22008295 450 991030026030332120200701072604.03-319-14648-310.1007/978-3-319-14648-5(CKB)3710000000416778(SSID)ssj0001501725(PQKBManifestationID)11921203(PQKBTitleCode)TC0001501725(PQKBWorkID)11446222(PQKB)10265496(DE-He213)978-3-319-14648-5(MiAaPQ)EBC5579135(MiAaPQ)EBC6314656(Au-PeEL)EBL5579135(OCoLC)1083469652(PPN)186030177(EXLCZ)99371000000041677820150506d2015 u| 0engurnn|008mamaatxtccrSobolev Spaces, Their Generalizations and Elliptic Problems in Smooth and Lipschitz Domains /by Mikhail S. Agranovich1st ed. 2015.Cham :Springer International Publishing :Imprint: Springer,2015.1 online resource (XIII, 331 p.) Springer Monographs in Mathematics,1439-7382Bibliographic Level Mode of Issuance: Monograph3-319-14647-5 Includes bibliographical references and index.Preface -- Preliminaries -- 1 The Spaces Hs. -- 2 Elliptic Equations and Elliptic Boundary Value Problems -- 3 The Spaces Hs and Second-Order Strongly Elliptic Systems in Lipschitz Domains -- 4 More General Spaces and Their Applications -- References -- Index.This book, which is based on several courses of lectures given by the author at the Independent University of Moscow, is devoted to Sobolev-type spaces and boundary value problems for linear elliptic partial differential equations. Its main focus is on problems in non-smooth (Lipschitz) domains for strongly elliptic systems.   The author, who is a prominent expert in the theory of linear partial differential equations, spectral theory, and pseudodifferential operators, has included his own very recent findings in the present book.   The book is well suited as a modern graduate textbook, utilizing a thorough and clear format that strikes a good balance between the choice of material and the style of exposition. It can be used both as an introduction to recent advances in elliptic equations and boundary value problems, and as a valuable survey and reference work. It also includes a good deal of new and extremely useful material not available in standard textbooks to date.   Graduate and post-graduate students, as well as specialists working in the fields of partial differential equations, functional analysis, operator theory, and mathematical physics will find this book particularly valuable.Springer Monographs in Mathematics,1439-7382Differential equations, PartialFunctional analysisOperator theoryPotential theory (Mathematics)Integral equationsMathematical physicsPartial Differential Equationshttps://scigraph.springernature.com/ontologies/product-market-codes/M12155Functional Analysishttps://scigraph.springernature.com/ontologies/product-market-codes/M12066Operator Theoryhttps://scigraph.springernature.com/ontologies/product-market-codes/M12139Potential Theoryhttps://scigraph.springernature.com/ontologies/product-market-codes/M12163Integral Equationshttps://scigraph.springernature.com/ontologies/product-market-codes/M12090Mathematical Physicshttps://scigraph.springernature.com/ontologies/product-market-codes/M35000Differential equations, Partial.Functional analysis.Operator theory.Potential theory (Mathematics)Integral equations.Mathematical physics.Partial Differential Equations.Functional Analysis.Operator Theory.Potential Theory.Integral Equations.Mathematical Physics.515.782Agranovich Mikhail Sauthttp://id.loc.gov/vocabulary/relators/aut536378MiAaPQMiAaPQMiAaPQBOOK9910300260303321Sobolevskie prostranstva, ikh obobshcheniya i ellipticheskie zadachi v oblastyakh s gladkoj i lipshitsevoj granitsej2440539UNINA