03784nam 22006735 450 991030018310332120200701085207.03-319-12679-210.1007/978-3-319-12679-1(CKB)3710000000315943(EBL)1966000(SSID)ssj0001408324(PQKBManifestationID)11746697(PQKBTitleCode)TC0001408324(PQKBWorkID)11346665(PQKB)10877915(DE-He213)978-3-319-12679-1(MiAaPQ)EBC1966000(PPN)183153359(EXLCZ)99371000000031594320141211d2015 u| 0engur|n|---|||||txtccrNeuroanatomy and Pathology of Sporadic Alzheimer's Disease /by Heiko Braak, Kelly Del Tredici1st ed. 2015.Cham :Springer International Publishing :Imprint: Springer,2015.1 online resource (168 p.)Advances in Anatomy, Embryology and Cell Biology,0301-5556 ;215"With 48 figures."3-319-12678-4 Includes bibliographical references.Prologue -- General Morphology of Alzheimer-associated intraneuronal pathology -- Consistent and systematic changes in the distribution pattern of intraneuronal inclusions render staging possible -- Basic organization of involved structures -- Presymptomatic stages -- General morphology of Alzheimer-associated extracellular pathology -- Symptomatic stages -- The progression of cortical lesions mimics the pattern of myelination in reverse order -- Tauopathies -- CSF biomarkers and imaging techniques -- The staging hypothesis: assumptions, challenges, potential -- Technical considerations.   .As indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD-associated pathology is illustrated from its beginnings (sometimes even in childhood) to its final form, which is reached late in life. The AD process commences much earlier than the clinically recognizable phase of the disorder, and its timeline includes an extended preclinical phase. The further the pendulum swings away from the symptomatic final stages towards the early pathology, the more obvious the lesions become, although from a standpoint of severity they are more unremarkable and thus frequently overlooked during routine neuropathological assessment. For this reason, the authors deal with the hallmark lesions in the early phases of the AD process in considerable detail.Advances in Anatomy, Embryology and Cell Biology,0301-5556 ;215NeurosciencesPathologyGeriatricsNeuroscienceshttps://scigraph.springernature.com/ontologies/product-market-codes/B18006Pathologyhttps://scigraph.springernature.com/ontologies/product-market-codes/H4800XGeriatrics/Gerontologyhttps://scigraph.springernature.com/ontologies/product-market-codes/H33150Neurosciences.Pathology.Geriatrics.Neurosciences.Pathology.Geriatrics/Gerontology.616.83107Braak Heikoauthttp://id.loc.gov/vocabulary/relators/aut1058353Del Tredici Kellyauthttp://id.loc.gov/vocabulary/relators/autMiAaPQMiAaPQMiAaPQBOOK9910300183103321Neuroanatomy and Pathology of Sporadic Alzheimer's Disease2499521UNINA