06266nam 2201585z- 450 991058021580332120220706(CKB)5690000000011929(oapen)https://directory.doabooks.org/handle/20.500.12854/87543(oapen)doab87543(EXLCZ)99569000000001192920202207d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierNanomedicine Formulations Based on PLGA Nanoparticles for Diagnosis, Monitoring and Treatment of Disease: From Bench to BedsideBaselMDPI - Multidisciplinary Digital Publishing Institute20221 online resource (296 p.)3-0365-4490-9 3-0365-4489-5 Nanomedicine is among the most promising emerging fields that can provide innovative and radical solutions to unmet needs in pharmaceutical formulation development. Encapsulation of active pharmaceutical ingredients within nano-size carriers offers several benefits, namely, protection of the therapeutic agents from degradation, their increased solubility and bioavailability, improved pharmacokinetics, reduced toxicity, enhanced therapeutic efficacy, decreased drug immunogenicity, targeted delivery, and simultaneous imaging and treatment options with a single system.Poly(lactide-co-glycolide) (PLGA) is one of the most commonly used polymers in nanomedicine formulations due to its excellent biocompatibility, tunable degradation characteristics, and high versatility. Furthermore, PLGA is approved by the European Medicines Agency (EMA) and the Food and Drug Administration (FDA) for use in pharmaceutical products. Nanomedicines based on PLGA nanoparticles can offer tremendous opportunities in the diagnosis, monitoring, and treatment of various diseases.This Special Issue aims to focus on the bench-to-bedside development of PLGA nanoparticles including (but not limited to) design, development, physicochemical characterization, scale-up production, efficacy and safety assessment, and biodistribution studies of these nanomedicine formulations.Nanomedicine Formulations Based on PLGA Nanoparticles for Diagnosis, Monitoring and Treatment of DiseaseHistory of engineering and technologybicsscMaterials sciencebicsscTechnology: general issuesbicssc3D cultureamineangiotensinanimal modelanti-inflammatoryantigen releaseatorvastatin calciumbiocompatiblebiodegradableblood-brain barrier (BBB)brightnesscancercardiovascularcarrageenan induced inflammationcentral nervous systemchemoimmunotherapychitosanclinical translationconfocal microscopycoumarin 6current Good Manufacturing Practice (cGMP)Cy5.5cytotoxicitydesign of experimentsDiIdouble emulsion solvent evaporationdouble-emulsion methoddownstream processingdrug deliverydrug delivery systemdrug releasedrug release kinetics modelingdry powder inhalationemulsionencapsulationester and acid-end cappedfluorescent labelingFood and Drug Administration (FDA)H. pyloriimmune checkpoint blockadeimmunogenic cell deathin vitroin vivo neuroimagingIndomethacininline sonicationintracellular internalizationJO-4Katushkalyophilizationmas receptormethotrexatemicro-implantmicrofluidicmicrofluidicsminimally invasivemorphologynanomedicinenanoparticlenanoparticlesnanotechnologyneurodegenerative diseasesneuroprotective drugsnuclear medicineorthotopic tumorsparticle-sizePEGylationpharmacokinetics (PK) and biodistributionphotothermal therapyphthalocyaninePLA/PLGAPLGAPLGA diblock copolymerPLGA nanoparticlesPluronic triblock copolymerPNA5 glycopeptidepoly (lactic-co-glycolic acid) (PLGA)poly(lactic-co-glycolic acid)poly(lactic-co-glycolic acid) (PLGA)poly(lactic-co-glycolic) acidpoly(lactide-co-glycolide)polymeric nanoparticlespolyvinyl alcohol (PVA)porous PLGA particlesquantum yieldradiolabeled nanoparticlesrhodamine 123scale-up manufacturingsizeSKOVip-katsolid-state characterizationsolventsspheroidsstability of fluorescent labelstabilizerssucrosesustained releasetangential flow filtrationtrehaloseTurboFP635History of engineering and technologyMaterials scienceTechnology: general issuesTagit Oyaedt1313404Tagit OyaothBOOK9910580215803321Nanomedicine Formulations Based on PLGA Nanoparticles for Diagnosis, Monitoring and Treatment of Disease: From Bench to Bedside3031389UNINA07199nam 22008535 450 991029976440332120251230065856.03-319-11418-210.1007/978-3-319-11418-7(CKB)3710000000324644(EBL)1965295(OCoLC)908083198(SSID)ssj0001408170(PQKBManifestationID)11787290(PQKBTitleCode)TC0001408170(PQKBWorkID)11346177(PQKB)11713303(DE-He213)978-3-319-11418-7(MiAaPQ)EBC1965295(PPN)183148940(EXLCZ)99371000000032464420141226d2015 u| 0engur|n|---|||||txtccrAdvances in Architectural Geometry 2014 /edited by Philippe Block, Jan Knippers, Niloy J. Mitra, Wenping Wang1st ed. 2015.Cham :Springer International Publishing :Imprint: Springer,2015.1 online resource (379 p.)Description based upon print version of record.3-319-11417-4 Includes bibliographical references at the end of each chapters.Simulation of Aggregate Structures in Architecture: Distinct-Element Modeling of Synthetic Non-Convex Granulates: K. Dierichs and A. Menges -- Post-Tensioned Discrete Concrete Elements Developed For Free-Form Construction: O.E. Pedersen, N.M. Larsen and D. Pigram -- Modular Fibrous Morphologies: Computational Design, Simulation and Fabrication of Differentiated Fibre Composite Building Components: S. Parascho, M. Dörstelmann, M. Prado, A. Menges and J. Knippers -- Application of Reinforced Structural Glass-Timber Elements in Architecture: Ph. Eversmann, P. Ehret, Ch. Louter and M. Santarsiero -- Gaudi’s Puffy Jacket: A Method for the Implementation of Fabric Slump Casting in the Construction of Thin-Shell Funicular Vault Structures: I. Maxwell and D. Pigram -- New Opportunities to Optimize Structural Designs in Metal by Using Additive Manufacturing: Salomé Galjaard, S. Hofman and S. Ren -- Interactive Modeling of Architectural Freeform Structures - Combining Geometry with Fabrication and Statics: C. Jiang, C. Tang, M. Tomicic, J. Wallner and H. Pottmann -- Computational Integration of Robotic Fabrication, Architectural Geometry and Structural Design for Biomimetic Lightweight Timber Plate Shells: O.D. Krieg, T. Schwinn, A. Menges, J.-M. Li, J. Knippers, A. Schmitt and V. Schwieger -- Form Finding of Twisted Interlaced Structures: a Hybrid Approach: S.S. Nabaei, O. Baverel and Y. Weinand -- A Graph-Based Approach for Discovery of Stable Deconstruction Sequences: L. Beyeler, J.-Ch. Bazin and E. Whiting -- Advanced Topology Optimization Methods for Conceptual Architectural Design: N. Aage, O. Amir, A. Clausen, L. Hadar, D. Maier and Asbjørn Søndergaard -- Computational Design and Construction of Notch-free Reciprocal Frame Structures: N. Mellado, P. Chi-Wing Fu, P. Song, X. Yan and N. Mitra -- Surface Panelization Using Periodic Conformal Maps -- T.Röhrig, S. Sechelmann, A. Kycia and M. Fleischmann -- Geometrical Solution Space for Grid Structure with Double-Walled Edge: R. Kalvo and A. Sevtsuk -- Designing Symmetric Derivatives of the Miura-ori: P. Sareh and S.D. Guest -- Algorithmic Optimization of the Cross-Section Distribution Across a Steel Framework Structure: L.Lombard, J. Lalande and F. Consigny -- Planar Panelisation with Extreme Repetition: M. Huard, M. Eigensatz and P. Bompas -- Interlocking Folded Plate - Integrated Mechanical Attachment for Structural Timber Panels: Ch. Robeller, A. Stitic, P. Mayencourt and Y. Weinand -- The Ongreening Pavilion: J. Harding, W. Pearson, H. Lewis and S. Melville -- The Caterpillar Gallery: Quadric Surface Theorems, Parametric Design and Digital Fabrication: R. Narvaez-Rodriguez, A. Martin-Pastor and M. Aguilar-Alejandre -- Constructing Complex Geometries: A Case Study on the Cité des Civilisations du Vin in Bordeaux, France: B. Soquier, R. Mizzi, D. Dureisseix and J.-B. Valette -- The Geometry of the Error: Y. Adilenidou -- LAR-ABC, a Representation of Architectural Geometry From Concept of Spaces, to Design of Building Fabric, to Construction Simulation: A. Paoluzzi, E. Marino and F. Spini -- Offset Folding: A. Stahr and H. Loeschke.This book contains 24 technical papers presented at the fourth edition of the Advances in Architectural Geometry conference, AAG 2014, held in London, England, September 2014. It offers engineers, mathematicians, designers, and contractors insight into the efficient design, analysis, and manufacture of complex shapes, which will help open up new horizons for architecture. The book examines geometric aspects involved in architectural design, ranging from initial conception to final fabrication. It focuses on four key topics: applied geometry, architecture, computational design, and also practice in the form of case studies. In addition, the book also features algorithms, proposed implementation, experimental results, and illustrations. Overall, the book presents both theoretical and practical work linked to new geometrical developments in architecture. It gathers the diverse components of the contemporary architectural tendencies that push the building envelope towards free form in order to respond to multiple current design challenges. With its introduction of novel computational algorithms and tools, this book will prove an ideal resource to both newcomers to the field as well as advanced practitioners.MathematicsComputer simulationComputer-aided engineeringGeometry, DifferentialCivil engineeringArtsArchitectureMathematicsApplications of MathematicsComputer ModellingComputer-Aided Engineering (CAD, CAE) and DesignDifferential GeometryCivil EngineeringMathematics in Art and ArchitectureMathematics.Computer simulation.Computer-aided engineering.Geometry, Differential.Civil engineering.Arts.ArchitectureMathematics.Applications of Mathematics.Computer Modelling.Computer-Aided Engineering (CAD, CAE) and Design.Differential Geometry.Civil Engineering.Mathematics in Art and Architecture.003.3510516.36519Block Philippeedthttp://id.loc.gov/vocabulary/relators/edtKnippers Janedthttp://id.loc.gov/vocabulary/relators/edtMitra Niloy Jedthttp://id.loc.gov/vocabulary/relators/edtWang Wenpingedthttp://id.loc.gov/vocabulary/relators/edtBOOK9910299764403321Advances in Architectural Geometry 20141564832UNINA