04872nam 22007575 450 991029958210332120200705090035.04-431-56514-010.1007/978-4-431-56514-7(CKB)4100000001794726(DE-He213)978-4-431-56514-7(MiAaPQ)EBC5217699(PPN)223954381(EXLCZ)99410000000179472620180110d2018 u| 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierBone Adaptation In Silico Approach /by Yoshitaka Kameo, Ken-ichi Tsubota, Taiji Adachi1st ed. 2018.Tokyo :Springer Japan :Imprint: Springer,2018.1 online resource (XIV, 209 p. 93 illus., 24 illus. in color.) Frontiers of Biomechanics,2199-8515 ;24-431-56512-4 Includes bibliographical references at the end of each chapters and index.Overview: In Silico Approaches to Understand Bone Adaptation -- Microscopic Fluid Flow Analysis in an Osteocyte Canaliculus -- Macroscopic Fluid Flow Analysis in a Poroelastic Trabecula -- Estimation of Bone Permeability for Poroelastic Analysis -- Modeling Trabecular Bone Adaptation Induced by Flow Stimuli to Osteocytes -- Effects of Local Bending Load on Trabecular Bone Adaptation -- Cancellous Bone Adaptation Predicted by Remodeling Simulations -- Trabecular Surface Remodeling toward Uniform Local Stress State -- Spatial and Temporal Regulation of Cancellous Bone Structure by Trabecular Surface Remodeling -- Comparison of Mechanical Quantities as Bone Remodeling Stimuli -- Trabecular Surface Remodeling Simulation of Cancellous Bone Using Image-Based Voxel Finite Element Models -- Functional Adaptation of Cancellous Bone in Human Proximal Femur -- 3D Trabecular Remodeling in Human Proximal Femur: Approach to Understanding Wolff’s Law -- Trabecular Structural Changes in a Vertebral Body with a Fixation Screw.This book focuses on the systems biomechanics of bone remodeling that provide a multiscale platform for bone adaptation, spanning the cellular, tissue, and organ levels. The mathematical model explained in each section provides concrete examples of in silico approaches for bone adaptation. It will be immensely useful for readers interested in bone morphology and metabolism and will serve as an effective bridge connecting mechanics, cellular and molecular biology, and medical sciences. These in silico approaches towards exploring the mechanisms by which the functioning of dynamic living systems is established and maintained have potential for facilitating the efforts of graduate students and young researchers pioneering new frontiers of biomechanics.Frontiers of Biomechanics,2199-8515 ;2Biomedical engineeringOrthopedicsBiomathematicsBiophysicsBiophysicsRegenerative medicineTissue engineeringComputer simulationBiomedical Engineering and Bioengineeringhttps://scigraph.springernature.com/ontologies/product-market-codes/T2700XOrthopedicshttps://scigraph.springernature.com/ontologies/product-market-codes/H45000Physiological, Cellular and Medical Topicshttps://scigraph.springernature.com/ontologies/product-market-codes/M31020Biological and Medical Physics, Biophysicshttps://scigraph.springernature.com/ontologies/product-market-codes/P27008Regenerative Medicine/Tissue Engineeringhttps://scigraph.springernature.com/ontologies/product-market-codes/L16080Simulation and Modelinghttps://scigraph.springernature.com/ontologies/product-market-codes/I19000Biomedical engineering.Orthopedics.Biomathematics.Biophysics.Biophysics.Regenerative medicine.Tissue engineering.Computer simulation.Biomedical Engineering and Bioengineering.Orthopedics.Physiological, Cellular and Medical Topics.Biological and Medical Physics, Biophysics.Regenerative Medicine/Tissue Engineering.Simulation and Modeling.610.28Kameo Yoshitakaauthttp://id.loc.gov/vocabulary/relators/aut1063483Tsubota Ken-ichiauthttp://id.loc.gov/vocabulary/relators/autAdachi Taijiauthttp://id.loc.gov/vocabulary/relators/autBOOK9910299582103321Bone Adaptation2532672UNINA