04022nam 22006015 450 991029924760332120200701210059.01-4471-6693-010.1007/978-1-4471-6693-1(CKB)3710000000399775(EBL)2096777(SSID)ssj0001500977(PQKBManifestationID)11852303(PQKBTitleCode)TC0001500977(PQKBWorkID)11523029(PQKB)10538805(DE-He213)978-1-4471-6693-1(MiAaPQ)EBC2096777(PPN)258850434(PPN)185489796(EXLCZ)99371000000039977520150413d2015 u| 0engur|n|---|||||txtccrComparative Gene Finding Models, Algorithms and Implementation /by Marina Axelson-Fisk2nd ed. 2015.London :Springer London :Imprint: Springer,2015.1 online resource (396 p.)Computational Biology,1568-2684 ;20Description based upon print version of record.1-4471-6692-2 Includes bibliographical references at the end of each chapters and index.Introduction -- Single Species Gene Finding -- Sequence Alignment -- Comparative Gene Finding -- Gene Structure Submodels -- Parameter Training -- Implementation of a Comparative Gene Finder -- Annotation Pipelines for Next Generation Sequencing Projects.This unique text/reference presents a concise guide to building computational gene finders, and describes the state of the art in computational gene finding methods, with a particular focus on comparative approaches. Fully updated and expanded, this new edition examines next-generation sequencing (NGS) technology, including annotation pipelines for NGS data. The book also discusses conditional random fields, enhancing the broad coverage of topics spanning probability theory, statistics, information theory, optimization theory, and numerical analysis. Topics and features: Introduces the fundamental terms and concepts in the field, and provides an historical overview of algorithm development Discusses algorithms for single-species gene finding, and approaches to pairwise and multiple sequence alignments, then describes how the strengths in both areas can be combined to improve the accuracy of gene finding Explores the gene features most commonly captured by a computational gene model, and explains the basics of parameter training Illustrates how to implement a comparative gene finder, reviewing the different steps and accuracy assessment measures used to debug and benchmark the software Examines NGS techniques, and how to build a genome annotation pipeline, discussing sequence assembly, de novo repeat masking, and gene prediction (NEW) Postgraduate students, and researchers wishing to enter the field quickly, will find this accessible text a valuable source of insights and examples. A suggested course outline for instructors is provided in the preface. Dr. Marina Axelson-Fisk is an Associate Professor at the Department of Mathematical Sciences of Chalmers University of Technology, Gothenburg, Sweden.Computational Biology,1568-2684 ;20BioinformaticsComputational Biology/Bioinformaticshttps://scigraph.springernature.com/ontologies/product-market-codes/I23050Bioinformaticshttps://scigraph.springernature.com/ontologies/product-market-codes/L15001Bioinformatics.Computational Biology/Bioinformatics.Bioinformatics.572.860285Axelson-Fisk Marinaauthttp://id.loc.gov/vocabulary/relators/aut1059827MiAaPQMiAaPQMiAaPQBOOK9910299247603321Comparative Gene Finding2508549UNINA