03261nam 22007335 450 991029923000332120260810170141.03-319-14914-810.1007/978-3-319-14914-1(CKB)3710000000342593(EBL)1966836(SSID)ssj0001424573(PQKBManifestationID)11891915(PQKBTitleCode)TC0001424573(PQKBWorkID)11367548(PQKB)10906036(DE-He213)978-3-319-14914-1(MiAaPQ)EBC1966836(PPN)183518187(EXLCZ)99371000000034259320150122d2015 u| 0engur|n|---|||||txtccrProtein Homology Detection Through Alignment of Markov Random Fields Using MRFalign /by Jinbo Xu, Sheng Wang, Jianzhu Ma1st ed. 2015.Cham :Springer International Publishing :Imprint: Springer,2015.1 online resource (59 p.)SpringerBriefs in Computer Science,2191-5776Description based upon print version of record.3-319-14913-X Includes bibliographical references.Introduction -- Method -- Software -- Experiments and Results -- Conclusion.This work covers sequence-based protein homology detection, a fundamental and challenging bioinformatics problem with a variety of real-world applications. The text first surveys a few popular homology detection methods, such as Position-Specific Scoring Matrix (PSSM) and Hidden Markov Model (HMM) based methods, and then describes a novel Markov Random Fields (MRF) based method developed by the authors. MRF-based methods are much more sensitive than HMM- and PSSM-based methods for remote homolog detection and fold recognition, as MRFs can model long-range residue-residue interaction. The text also describes the installation, usage and result interpretation of programs implementing the MRF-based method.SpringerBriefs in Computer Science,2191-5776BioinformaticsComputer scienceMathematicsMathematical statisticsBiometryComputational and Systems BiologyProbability and Statistics in Computer ScienceBioinformaticsBiostatisticsBioinformatics.Computer scienceMathematics.Mathematical statistics.Biometry.Computational and Systems Biology.Probability and Statistics in Computer Science.Bioinformatics.Biostatistics.004005.55519.5570285Hŏ Kŭm-p'aauthttp://id.loc.gov/vocabulary/relators/aut1868555Wang Shengauthttp://id.loc.gov/vocabulary/relators/autMa Jianzhuauthttp://id.loc.gov/vocabulary/relators/autBOOK9910299230003321Protein Homology Detection Through Alignment of Markov Random Fields4476519UNINA