03355nam 22006495 450 991029864200332120200704114857.03-642-54304-910.1007/978-3-642-54304-3(CKB)3710000000089218(EBL)1783256(OCoLC)872577832(SSID)ssj0001186498(PQKBManifestationID)11813505(PQKBTitleCode)TC0001186498(PQKBWorkID)11240261(PQKB)11574015(MiAaPQ)EBC1783256(DE-He213)978-3-642-54304-3(PPN)176751866(EXLCZ)99371000000008921820140226d2014 u| 0engur|n|---|||||txtccrTotal Synthesis of (±)-Maoecrystal V /by Jianxian Gong1st ed. 2014.Berlin, Heidelberg :Springer Berlin Heidelberg :Imprint: Springer,2014.1 online resource (146 p.)Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5053Description based upon print version of record.3-642-54303-0 Inclues bibliographical references.Research Background for Natural Product Maoecrystal V and Its Family -- The Model Study of Natural Product Maoecrystal V -- The total synthesis study of Maoecrystal V -- Summary.In this thesis, the author describes the total synthesis of natural product Maoecrystal V in detail. In the first part of the thesis, the author introduces the research background and reviews the research progress in total synthesis of Maoecrystal V. In the second part, the author develops a novel and concise approach for the stereoselective construction of the tetracyclic model system of Maoecrystal V. The model system is accomplished in 8 steps with 20% yield. In the third part, the author describes the first successful total synthesis of Maoecrystal V and investigates four strategies for constructing the key tetrahydrofuran oxa-bridge skeleton. The total synthesis starts from a known compound and is accomplished in 17 steps with 1.2% yield. The successful total synthesis of Maoecrystal V will contribute to the development of efficient synthetic strategies for natural products and other compounds with complex structures.Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5053Organic chemistryMedicinal chemistryCatalysisOrganic Chemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/C19007Medicinal Chemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/C28000Catalysishttps://scigraph.springernature.com/ontologies/product-market-codes/C29000Organic chemistry.Medicinal chemistry.Catalysis.Organic Chemistry.Medicinal Chemistry.Catalysis.547.7547.70459Gong Jianxianauthttp://id.loc.gov/vocabulary/relators/aut1060636BOOK9910298642003321Total Synthesis of (±)-Maoecrystal V2514710UNINA