03975nam 22006735 450 991029862730332120200705192724.03-319-13584-810.1007/978-3-319-13584-7(CKB)3710000000311694(EBL)1968605(OCoLC)908089889(SSID)ssj0001408004(PQKBManifestationID)11773986(PQKBTitleCode)TC0001408004(PQKBWorkID)11412381(PQKB)11595587(DE-He213)978-3-319-13584-7(MiAaPQ)EBC1968605(PPN)183154150(EXLCZ)99371000000031169420141203d2015 u| 0engur|n|---|||||txtccrHolographic Sensors /by Ali Kemal Yetisen1st ed. 2015.Cham :Springer International Publishing :Imprint: Springer,2015.1 online resource (175 p.)Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5053Description based upon print version of record.3-319-13583-X Includes bibliographical references.Introduction -- Materials and Methods -- pH-Responsive Holograms -- Divalent Metal Cation Selective Holographic Sensors -- Glucose-Responsive Holograms and Clinical Trials on Diabetic Patients -- A Smartphone Algorithm for the Quantification of Colorimetric Assays -- Final Discussion.This thesis presents a theoretical and experimental approach for the rapid fabrication, optimization and testing of holographic sensors for the quantification of pH, organic solvents, metal cations, and glucose in solutions. Developing non-invasive and reusable diagnostics sensors that can be easily manufactured will support the monitoring of high-risk individuals in any clinical or point-of-care setting. Sensor fabrication approaches outlined include silver-halide chemistry, laser ablation and photopolymerization. The sensors employ off-axis Bragg diffraction gratings of ordered silver nanoparticles and localized refractive index changes in poly (2-hydroxyethyl methacrylate) and polyacrylamide films. The sensors exhibited reversible Bragg peak shifts, and diffracted the spectrum of narrow-band light over the wavelength range λpeak ≈ 495-1100 nm. Clinical trials of glucose sensors in the urine samples of diabetic patients demonstrated that they offer superior performance compared to commercial high-throughput urinalysis devices. Lastly, a generic smartphone application to quantify colorimetric tests was developed and tested for both Android and iOS operating systems. The sensing platform and smartphone application may have implications for the development of low-cost, reusable and equipment-free point-of-care diagnostic devices.Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5053Chemical engineeringMedicinal chemistryLaboratory medicineIndustrial Chemistry/Chemical Engineeringhttps://scigraph.springernature.com/ontologies/product-market-codes/C27000Medicinal Chemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/C28000Laboratory Medicinehttps://scigraph.springernature.com/ontologies/product-market-codes/B15007Chemical engineering.Medicinal chemistry.Laboratory medicine.Industrial Chemistry/Chemical Engineering.Medicinal Chemistry.Laboratory Medicine.54610724615.19660Yetisen Ali Kemalauthttp://id.loc.gov/vocabulary/relators/aut991424BOOK9910298627303321Holographic Sensors2268939UNINA