04123nam 22007815 450 991029861880332120200701101121.03-319-14962-810.1007/978-3-319-14962-2(CKB)3710000000359082(EBL)1998177(SSID)ssj0001451969(PQKBManifestationID)11890627(PQKBTitleCode)TC0001451969(PQKBWorkID)11498446(PQKB)11578551(DE-He213)978-3-319-14962-2(MiAaPQ)EBC1998177(PPN)184499240(EXLCZ)99371000000035908220150216d2015 u| 0engur|n|---|||||txtccrDynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells Mathematical Modeling and Experimental Observations /by Iman Tavassoly1st ed. 2015.Cham :Springer International Publishing :Imprint: Springer,2015.1 online resource (99 p.)Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5053"Doctoral thesis accepted by Virginia Polytechnic Institute and State University, USA."3-319-14961-X Includes bibliographical references at the end of each chapters.Introduction -- Mathematical Modeling of the Interplay of Autophagy and Apoptosis -- An Experimental Framework to Study the Dynamics of Autophagic Response -- Conclusions -- Source Code.This interdisciplinary thesis introduces a systems biology approach to study the cell fate decision mediated by autophagy. A mathematical model of interaction between Autophagy and Apoptosis in mammalian cells is proposed. In this dynamic model autophagy acts as a gradual response to stress (Rheostat) that delays the initiation of bistable switch of apoptosis to give the cells an opportunity to survive. The author shows that his dynamical model is consistent with existing quantitative measurements of time courses of autophagic responses to cisplatin treatment. To understand the function of this response in cancer cells, he has provided a systems biology experimental framework to study quantitative and dynamical aspects of autophagy in single cancer cells using live-cell imaging and quantitative fluorescence microscopy. This framework can provide new insights on function of autophagic response in cancer cells.Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5053BiomaterialsBioinformaticsCancerResearchCytologyBiophysicsBiophysicsBiomaterialshttps://scigraph.springernature.com/ontologies/product-market-codes/Z13000Computational Biology/Bioinformaticshttps://scigraph.springernature.com/ontologies/product-market-codes/I23050Cancer Researchhttps://scigraph.springernature.com/ontologies/product-market-codes/B11001Cell Biologyhttps://scigraph.springernature.com/ontologies/product-market-codes/L16008Biological and Medical Physics, Biophysicshttps://scigraph.springernature.com/ontologies/product-market-codes/P27008Biomaterials.Bioinformatics.CancerResearch.Cytology.Biophysics.Biophysics.Biomaterials.Computational Biology/Bioinformatics.Cancer Research.Cell Biology.Biological and Medical Physics, Biophysics.571.936Tavassoly Imanauthttp://id.loc.gov/vocabulary/relators/aut974039MiAaPQMiAaPQMiAaPQBOOK9910298618803321Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells2217256UNINA