04835nam 22007935 450 991029860630332120200630233345.03-319-72002-310.1007/978-3-319-72002-9(CKB)3840000000347722(MiAaPQ)EBC5287492(DE-He213)978-3-319-72002-9(PPN)224640690(EXLCZ)99384000000034772220180209d2018 u| 0engurcnu||||||||rdacontentrdamediardacarrierAmorphous Drugs Benefits and Challenges /by Marzena Rams-Baron, Renata Jachowicz, Elena Boldyreva, Deliang Zhou, Witold Jamroz, Marian Paluch1st ed. 2018.Cham :Springer International Publishing :Imprint: Springer,2018.1 online resource (230 pages) illustrations (some color)3-319-72001-5 Includes bibliographical references at the end of each chapters and index.Why amorphous drugs? -- Order vs. disorder in the solid state -- Amorphous drug solubility and absorption enhancement -- Amorphous drug preparation methods -- Physical instability - a key problem of amorphous drugs -- Amorphous drug formulation.This book explains theoretical and technological aspects of amorphous drug formulations. It is intended for all those wishing to increase their knowledge in the field of amorphous pharmaceuticals. Conversion of crystalline material into the amorphous state, as described in this book, is a way to overcome limited water solubility of drug formulations, in this way enhancing the chemical activity and bioavailability inside the body. Written by experts from various fields and backgrounds, the book introduces to fundamental physical aspects (explaining differences between the ordered and the disordered solid states, the enhancement of solubility resulting from drugs amorphization, physical instability and how it can be overcome) as well as preparation and formulation procedures to produce and stabilize amorphous pharmaceuticals. Readers will thus gain a well-funded understanding and find a multi-faceted discussion of the properties and advantages of amorphous drugs and of the challenges in producing and stabilizing them. The book is an ideal source of information for researchers and students as well as professionals engaged in research and development of amorphous pharmaceutical products. .Medicinal chemistryPharmaceutical technologyPhase transitions (Statistical physics)ThermodynamicsCeramicsGlassComposites (Materials)Composite materialsBiomedical engineeringMedicinal Chemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/C28000Pharmaceutical Sciences/Technologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B21010Phase Transitions and Multiphase Systemshttps://scigraph.springernature.com/ontologies/product-market-codes/P25099Thermodynamicshttps://scigraph.springernature.com/ontologies/product-market-codes/P21050Ceramics, Glass, Composites, Natural Materialshttps://scigraph.springernature.com/ontologies/product-market-codes/Z18000Biomedical Engineering and Bioengineeringhttps://scigraph.springernature.com/ontologies/product-market-codes/T2700XMedicinal chemistry.Pharmaceutical technology.Phase transitions (Statistical physics).Thermodynamics.Ceramics.Glass.Composites (Materials).Composite materials.Biomedical engineering.Medicinal Chemistry.Pharmaceutical Sciences/Technology.Phase Transitions and Multiphase Systems.Thermodynamics.Ceramics, Glass, Composites, Natural Materials.Biomedical Engineering and Bioengineering.615.19Rams-Baron Marzenaauthttp://id.loc.gov/vocabulary/relators/aut1061410Jachowicz Renataauthttp://id.loc.gov/vocabulary/relators/autBoldyreva Elenaauthttp://id.loc.gov/vocabulary/relators/autZhou Deliangauthttp://id.loc.gov/vocabulary/relators/autJamroz Witoldauthttp://id.loc.gov/vocabulary/relators/autPaluch Marianauthttp://id.loc.gov/vocabulary/relators/autBOOK9910298606303321Amorphous Drugs2518752UNINA