03709nam 22005535 450 991029859830332120200702221807.03-319-68097-810.1007/978-3-319-68097-2(CKB)3810000000358866(MiAaPQ)EBC5448147(DE-He213)978-3-319-68097-2(PPN)229493831(EXLCZ)99381000000035886620180628d2018 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierAntibacterials Volume I /edited by Jed F. Fisher, Shahriar Mobashery, Marvin J. Miller1st ed. 2018.Cham :Springer International Publishing :Imprint: Springer,2018.1 online resource (203 pages)Topics in Medicinal Chemistry,1862-2461 ;253-319-68096-X Antibacterial New Target Discovery: Sentinel Examples, Strategies, and Surveying Success -- The Antibiotic Future -- Synergistic Antibiotic Combinations -- Antibiotic Adjuvants -- Allosteric Inhibition of Bacterial Targets: An Opportunity for Discovery of Novel Antibacterial Classes -- Four Ways to Skin a Cat: Inhibition of Bacterial Topoisomerases Leading to the Clinic -- The Clinical Development of Antibacterial Drugs: A Guide for the Discovery Scientist.Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.Topics in Medicinal Chemistry,1862-2461 ;25Medicinal chemistryBiochemistryOrganic chemistryMedicinal Chemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/C28000Biochemistry, generalhttps://scigraph.springernature.com/ontologies/product-market-codes/L14005Organic Chemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/C19007Medicinal chemistry.Biochemistry.Organic chemistry.Medicinal Chemistry.Biochemistry, general.Organic Chemistry.616.92061Fisher Jed Fedthttp://id.loc.gov/vocabulary/relators/edtMobashery Shahriaredthttp://id.loc.gov/vocabulary/relators/edtMiller Marvin Jedthttp://id.loc.gov/vocabulary/relators/edtBOOK9910298598303321Antibacterials1566645UNINA