04331nam 22006975 450 991029858570332120200702042534.03-319-77706-810.1007/978-3-319-77706-1(CKB)4100000004243814(DE-He213)978-3-319-77706-1(MiAaPQ)EBC5404503(PPN)227399323(EXLCZ)99410000000424381420180528d2018 u| 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierCarbohydrate-Based Interactions at the Molecular and the Cellular Level /by Kieran L. Hudson1st ed. 2018.Cham :Springer International Publishing :Imprint: Springer,2018.1 online resource (XXIX, 198 p. 98 illus., 49 illus. in color.) Springer Theses, Recognizing Outstanding Ph.D. Research,2190-50533-319-77705-X Introduction -- Protein-Carbohydrate Interactions in Protein X-ray Crystal Structures -- The Nature of Protein-Carbohydrate Interactions -- The Modifiable Scaffold for Tissue Engineering -- Carbohydrate Modifiers for Tissue Engineering Scaffolds -- Conclusions and Future Directions -- Experimental Details and Supplementary Data.This book offers a clearly written and highly accessible account of two different aspects of carbohydrate chemistry. Carbohydrates are an essential component of life and have many important biological functions, but the details of how carbohydrates interact with other biomolecules to mediate biological signalling remain unclear. Firstly, this thesis details innovative methods to mine protein structural data to uncover new features of carbohydrate-based interactions. It also explains these findings using physical chemistry, specifically CH–pi interactions associated with the properties of the interacting partners. Carbohydrates are also critical for tissue growth and development, yet are underexploited in the materials science that underpins much of regenerative medicine. As such, the second part of this thesis describes a diverse array of techniques ranging from synthetic chemistry and enzymatic synthesis to prepare a wide variety of carbohydrates, and materials chemistry to prepare glycosylated hydrogels, to cell biology to determine the effects on cellular development for tissue engineering applications.Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5053CarbohydratesProteins Chemistry, Physical and theoreticalRegenerative medicineTissue engineeringPhysical chemistryAnalytical chemistryCarbohydrate Chemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/C19030Protein-Ligand Interactionshttps://scigraph.springernature.com/ontologies/product-market-codes/L14060Theoretical and Computational Chemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/C25007Regenerative Medicine/Tissue Engineeringhttps://scigraph.springernature.com/ontologies/product-market-codes/L16080Physical Chemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/C21001Analytical Chemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/C11006Carbohydrates.Proteins .Chemistry, Physical and theoretical.Regenerative medicine.Tissue engineering.Physical chemistry.Analytical chemistry.Carbohydrate Chemistry.Protein-Ligand Interactions.Theoretical and Computational Chemistry.Regenerative Medicine/Tissue Engineering.Physical Chemistry.Analytical Chemistry.547.78Hudson Kieran Lauthttp://id.loc.gov/vocabulary/relators/aut768763BOOK9910298585703321Carbohydrate-Based Interactions at the Molecular and the Cellular Level1566608UNINA