03852nam 22006735 450 991029858460332120200705172916.03-030-00853-310.1007/978-3-030-00853-6(CKB)4100000006999362(MiAaPQ)EBC5534440(DE-He213)978-3-030-00853-6(PPN)231462220(EXLCZ)99410000000699936220181001d2018 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierGold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins[electronic resource] /by Raphael Enoque Ferraz de Paiva1st ed. 2018.Cham :Springer International Publishing :Imprint: Springer,2018.1 online resource (184 pages)Springer Theses, Recognizing Outstanding Ph.D. Research,2190-50533-030-00852-5 Au(I)-phosphine series design -- Probing the Protein: Ion Mobility Spectrometry -- Probing Gold: X-ray Absorption Spectroscopy -- Probing Cells: Cytotoxicity Evaluation -- Au(III) series with k2C,N and k2N,N' ligands -- "Dual Probe" X-ray Absorption Spectroscopy.This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C–S coupling.Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5053Inorganic chemistryOrganometallic chemistry Proteins Mass spectrometryBioorganic chemistryImmunologyInorganic Chemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/C16008Organometallic Chemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/C19020Protein-Ligand Interactionshttps://scigraph.springernature.com/ontologies/product-market-codes/L14060Mass Spectrometryhttps://scigraph.springernature.com/ontologies/product-market-codes/C11010Bioorganic Chemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/C19010Immunologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B14000Inorganic chemistry.Organometallic chemistry .Proteins .Mass spectrometry.Bioorganic chemistry.Immunology.Inorganic Chemistry.Organometallic Chemistry.Protein-Ligand Interactions.Mass Spectrometry.Bioorganic Chemistry.Immunology.571.845Ferraz de Paiva Raphael Enoqueauthttp://id.loc.gov/vocabulary/relators/aut1059031BOOK9910298584603321Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins2503745UNINA