01153nam0-22003491i-450-99000797861040332120080220100420.088-8358-296-9000797861FED01000797861(Aleph)000797861FED0100079786120041222d2002----km-y0itay50------baitaITa-------001yy<<I >>processi di apprendimento nella scuola dell'autonomiaanalisi disciplinare e personalizzazione dei talentia cura di Maria Renata Zanchincontributi di D. Antonello... [et al.]RomaArmando©2002111 p.ill.24 cm<<Il >>farsi della conoscenzaStrumentiApprendimentoPsicologia educativaScuola secondariaDidattica373.13Zanchin,Maria RenataAntonello,DanielaITUNINARICAUNIMARCBK990007978610403321373.13 ZAN 1Bibl. 45689FLFBCFLFBCProcessi di apprendimento nella scuola dell'autonomia751293UNINA03592nam 22005775 450 991029843860332120251116195616.03-319-73238-210.1007/978-3-319-73238-1(CKB)4100000003359275(MiAaPQ)EBC5372066(DE-He213)978-3-319-73238-1(PPN)226698580(EXLCZ)99410000000335927520180425d2018 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierAccelerated Path to Cures /edited by Josep Bassaganya-Riera1st ed. 2018.Cham :Springer International Publishing :Imprint: Springer,2018.1 online resource (88 pages)3-319-73237-4 Chapter 1: Introduction to Accelerated Path to Cures and Precision Medicine in Inflammatory Bowel Disease -- Chapter 2: Computer-Aided Drug Discovery -- Chapter 3: Preclinical Studies: Efficacy and Safety -- Chapter 4: From Nutritional Immunology to Drug Development -- Chapter 5: Development of Synthetic Patient Populations and In Silico Clinical Trials.Accelerated Path to Cures provides a transformative perspective on the power of combining advanced computational technologies, modeling, bioinformatics and machine learning approaches with nonclinical and clinical experimentation to accelerate drug development. This book discusses the application of advanced modeling technologies, from target identification and validation to nonclinical studies in animals to Phase 1-3 human clinical trials and post-approval monitoring, as alternative models of drug development. As a case of successful integration of computational modeling and drug development, we discuss the development of oral small molecule therapeutics for inflammatory bowel disease, from the application of docking studies to screening new chemical entities to the development of next-generation in silico human clinical trials from large-scale clinical data. Additionally, this book illustrates how modeling techniques, machine learning, and informatics can be utilized effectively at each stage of drug development to advance the progress towards predictive, preventive, personalized, precision medicine, and thus provide a successful framework for Path to Cures. .ImmunologyBioinformaticsMedical informaticsBioinformaticsComputational biologyImmunologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B14000Computational Biology/Bioinformaticshttps://scigraph.springernature.com/ontologies/product-market-codes/I23050Health Informaticshttps://scigraph.springernature.com/ontologies/product-market-codes/I23060Computer Appl. in Life Scienceshttps://scigraph.springernature.com/ontologies/product-market-codes/L17004Immunology.Bioinformatics.Medical informatics.Bioinformatics.Computational biology.Immunology.Computational Biology/Bioinformatics.Health Informatics.Computer Appl. in Life Sciences.615.190285Bassaganya-Riera Josepedthttp://id.loc.gov/vocabulary/relators/edtBOOK9910298438603321Accelerated Path to Cures2544113UNINA