04094nam 22005775 450 991029843060332120200630160737.03-319-90284-910.1007/978-3-319-90284-5(CKB)4100000004827227(DE-He213)978-3-319-90284-5(MiAaPQ)EBC5413864(PPN)229490956(EXLCZ)99410000000482722720180604d2018 u| 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierVoltage-gated Sodium Channels: Structure, Function and Channelopathies /edited by Mohamed Chahine1st ed. 2018.Cham :Springer International Publishing :Imprint: Springer,2018.1 online resource (X, 450 p. 80 illus., 55 illus. in color.) Handbook of Experimental Pharmacology,0171-2004 ;2463-319-90283-0 Preface -- Part I -- Evolution of voltage-gated sodium channels -- 1. Evolutionary History of Voltage-Gated Sodium Channels -- 2. Mining Protein Evolution for Insights into Mechanisms of Voltage-Dependent Sodium Channel Auxiliary Subunits. - Part II. The structural basis of sodium channel function -- 3. Structural and Functional Analysis of Sodium Channels Viewed from an Evolutionary Perspective -- 4. The Cardiac Sodium Channel and Its Protein Partners -- 5. : Posttranslational Modification of Sodium Channels -- 6. Sodium Channel Trafficking -- 7. pH Modulation of Voltage-Gated Sodium Channels -- 8. Regulation of Cardiac Voltage-Gated Sodium Channel by Kinases: Roles of Protein Kinases A and C -- Part III. Drugs and toxins interactions with sodium channels -- 9. Toxins That Affect Voltage-Gated Sodium Channels -- 10. Mechanisms of Drug Binding to Voltage-Gated Sodium Channels -- 11. Effects of Benzothiazolamines on Voltage-Gated Sodium Channels -- 12. Structural Models of Ligand-Bound Sodium Channels -- 13. Selective Ligands and Drug Discovery Targeting the Voltage-Gated Sodium Channel Nav1.7 -- Part IV. Pathophysiology of sodium channels -- 14. Sodium Channelopathies of Skeletal Muscle -- 15. Cardiac Arrhythmias Related to Sodium Channel Dysfunction -- 16. Translational Model Systems for Complex Sodium Channel Pathophysiology in Pain -- 17. Gating Pore Currents in Sodium Channels -- 18. Calculating the Consequences of Left-Shifted Nav Channel Activity in Sick Excitable Cells -- 19. Voltage-Gated Sodium Channel b Subunits and Their Related Diseases. .This book provides a timely state-of-the-art overview of voltage-gated sodium channels, their structure-function, their pharmacology and related diseases. Among the topics discussed are the structural basis of Na+ channel function, methodological advances in the study of Na+ channels, their pathophysiology and drugs and toxins interactions with these channels and their associated channelopathies.Handbook of Experimental Pharmacology,0171-2004 ;246PharmacologyHuman geneticsHuman physiologyProteins Pharmacology/Toxicologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B21007Human Geneticshttps://scigraph.springernature.com/ontologies/product-market-codes/B12008Human Physiologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B13004Protein Structurehttps://scigraph.springernature.com/ontologies/product-market-codes/L14050Pharmacology.Human genetics.Human physiology.Proteins .Pharmacology/Toxicology.Human Genetics.Human Physiology.Protein Structure.615Chahine Mohamededthttp://id.loc.gov/vocabulary/relators/edtBOOK9910298430603321Voltage gated sodium channels1078369UNINA