02891nam 22004575 450 991029842000332120200629131347.0981-13-0002-X10.1007/978-981-13-0002-8(CKB)4100000004244343(MiAaPQ)EBC5407231(DE-He213)978-981-13-0002-8(PPN)227401034(EXLCZ)99410000000424434320180531d2018 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierGlucose-sensing Receptor in Pancreatic Beta-cells /edited by Itaru Kojima1st ed. 2018.Singapore :Springer Singapore :Imprint: Springer,2018.1 online resource (73 pages)981-13-0001-1 1 HISTORY OF THE RESEARCH ON THE GLUCOSE RECEPTOR -- 2 Cell-surface Glucoreceptor Recognizing Anomers of Glucose in Pancreatic b-cells -- 3 KATP CHANNEL-INDEPENDENT PATHWAY and THE GLUCORECEPTOR -- 4 Signaling System Activated by the Glucose-sensing Receptor -- 5 The Role of the Glucose-sensing Receptor in Glucose-induced Insulin Secretion in Pancreatic b-cells.Since the 1970s, there has been much discussion about the “glucoreceptor” and “substrate site” and which of these two is the dominant theory, but new findings on the glucose-sensing receptor have now shed new light on the “glucoreceptor theory.” This volume reviews recent advances concerning the glucose-sensing receptor in pancreatic beta-cells. The history of research into pancreatic beta-cells is long and complex; accordingly, the first chapters present the history of this field and explain the hypothesis of insulin secretion mechanisms: “glucoreceptor theory”. Subsequent chapters examine the function and activity of the glucose-sensing receptor in pancreatic beta-cells, such as identification, channel pathway, receptor signal and physiological role. Readers will gain a thorough understanding of the glucose-sensing receptor and glucose metabolism in pancreatic beta-cells, new insights into the pathophysiology of diabetes, and learn about new targets for the treatment of diabetes. .Human physiologyEndocrinology Human Physiologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B13004Endocrinologyhttps://scigraph.springernature.com/ontologies/product-market-codes/H33053Human physiology.Endocrinology .Human Physiology.Endocrinology.573.377Kojima Itaruedthttp://id.loc.gov/vocabulary/relators/edtBOOK9910298420003321Glucose-sensing Receptor in Pancreatic Beta-cells2503037UNINA