04873nam 22008055 450 991029835180332120200703022544.01-4471-6311-710.1007/978-1-4471-6311-4(CKB)3710000000089053(EBL)1698286(OCoLC)874179142(SSID)ssj0001169924(PQKBManifestationID)11748780(PQKBTitleCode)TC0001169924(PQKBWorkID)11166246(PQKB)11606097(MiAaPQ)EBC1698286(DE-He213)978-1-4471-6311-4(PPN)176750487(EXLCZ)99371000000008905320140218d2014 u| 0engur|n|---|||||txtccrTrichloroethylene: Toxicity and Health Risks[electronic resource] /edited by Kathleen M. Gilbert, Sarah J. Blossom1st ed. 2014.London :Springer London :Imprint: Springer,2014.1 online resource (249 p.)Molecular and Integrative Toxicology,2168-4219Description based upon print version of record.1-4471-6310-9 Includes bibliographical references and index.History of TCE -- Trichloroethylene and autoimmunity in human and animal.-Hypersensitivity Dermatitis and Hepatitis -- Trichloroethylene-induced oxidative stress and autoimmunity.-Brain and Behavioral Changes in Rodent Models -- Role of Trichloroethylene in Parkinson’s disease -- Neuroimmune effects of developmental TCE exposure -- Environmental sensitivity to trichloroethylene (TCE) in the developing heart -- Trichloroethylene and Cancer -- Epigenetic Alterations Due to Trichloroethylene -- Mathematical Modeling and Trichloroethylene  .A comprehensive overview of the effects of trichloroethylene toxicity caused by real-life exposure levels highlighting how exposure to trichloroethylene may contribute to the etiology of several idiopathic human diseases. Discussion will focus on different kinds of modeling and how they may be used to predict functional consequences and to dissect the contribution of different mechanistic pathways, including potential mechanisms of action for trichloroethylene toxicity in different organ systems. It will explore the role of epigenetic alterations in trichloroethylene toxicity, this provides important mechanistic information and may also provide the basis for intervention therapy. Chapters will also explain how the risks from trichloroethylene exposure may be greater in certain populations based on genetic predisposition, age of exposure and co-exposure to other chemicals With contributions from international experts in the field, Trichloroethylene: Toxicity and Health Risks is an essential resource for researchers and clinicians in toxicology, immunology, medicine and public health as well as industry and government regulatory scientists involved in safety and health protection and epidemiologists, highlighting the need for interdisciplinary cooperation in solving issues of environmental toxicity.Molecular and Integrative Toxicology,2168-4219PharmacologyEpidemiologyMolecular biologyImmunologyMedical biochemistryEnvironmental healthPharmacology/Toxicologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B21007Epidemiologyhttps://scigraph.springernature.com/ontologies/product-market-codes/H63000Molecular Medicinehttps://scigraph.springernature.com/ontologies/product-market-codes/B1700XImmunologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B14000Medical Biochemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/H35005Environmental Healthhttps://scigraph.springernature.com/ontologies/product-market-codes/U18005Pharmacology.Epidemiology.Molecular biology.Immunology.Medical biochemistry.Environmental health.Pharmacology/Toxicology.Epidemiology.Molecular Medicine.Immunology.Medical Biochemistry.Environmental Health.615.902Gilbert Kathleen M1243450Gilbert Kathleen Medthttp://id.loc.gov/vocabulary/relators/edtBlossom Sarah Jedthttp://id.loc.gov/vocabulary/relators/edtBOOK9910298351803321Trichloroethylene: Toxicity and Health Risks2884161UNINA