04300nam 22006495 450 991029833520332120200629215958.01-4939-1683-110.1007/978-1-4939-1683-2(CKB)3710000000261813(EBL)1965022(OCoLC)894508684(SSID)ssj0001372163(PQKBManifestationID)11831404(PQKBTitleCode)TC0001372163(PQKBWorkID)11301847(PQKB)11517881(MiAaPQ)EBC1965022(DE-He213)978-1-4939-1683-2(PPN)182093883(EXLCZ)99371000000026181320141020d2014 u| 0engur|n|---|||||txtccrMolecular Genetics of Dysregulated pH Homeostasis /edited by Jen-Tsan Ashley Chi1st ed. 2014.New York, NY :Springer New York :Imprint: Springer,2014.1 online resource (158 p.)Description based upon print version of record.1-4939-1682-3 Includes bibliographical references at the end of eah chapters and index.Molecular Genetics of Acid Sensing and Response -- Part I: Sensing Acidity -- The molecular mechanism of cellular sensing of acidity -- The Molecular Basis of Sour Sensing in Mammals -- Function and Signaling of the pH-sensing G protein-coupled receptors in physiology and diseases -- Part II: Response to Acidity -- The MondoA-TXNIP checkpoint couples the acidic tumor microenvironment to cell metabolism -- Regulation of Renal Glutamine Metabolisms during Metabolic Acidosis -- Extracellular acidosis and cancer -- The genomic analysis of cellular responses and adaptions to extracellular acidosis -- Index.Most biological reactions and functions occur within a narrow range of pH. Any changes in the pH have great impacts on the biological function at every level, including protein folding, enzymatic activities and proliferation, and cell death. Therefore, maintaining the pH homeostasis at the local or systemic level is one of the highest priorities for all multicellular organisms. Many redundant mechanisms are in place to maintain the pH homeostasis, a topic that is well covered in scientific literature and in medical textbooks.  However, when the pH homeostasis is disrupted in various physiological adaptations and pathological situations, resulting acidity may trigger significant pathophysiological events, and modulate disease outcomes. Therefore, understanding how various cells sense and react to acidity have broad impact in a wide variety of human diseases including cancer, stroke, myocardial infarction, diabetes, and renal and infectious diseases. In this book, many investigators have summarized the molecular genetics on the detailed mechanisms by which different mammalian cells sense and respond to acidity. These chapters cover the acidity with broad impact in biological understanding and human diseases and review various sensing mechanisms and cellular responses to pH alterations in both physiological (taste, pain) and pathological (ischemia and cancers) settings. Furthermore, the authors present a broad spectrum of investigative approaches to cellular response to acidosis in a wide variety of human diseases.Human geneticsCell biologyMedicineHuman Geneticshttps://scigraph.springernature.com/ontologies/product-market-codes/B12008Cell Biologyhttps://scigraph.springernature.com/ontologies/product-market-codes/L16008Biomedicine, generalhttps://scigraph.springernature.com/ontologies/product-market-codes/B0000XHuman genetics.Cell biology.Medicine.Human Genetics.Cell Biology.Biomedicine, general.571.6599935610611.01816Chi Jen-Tsan Ashleyedthttp://id.loc.gov/vocabulary/relators/edtBOOK9910298335203321Molecular Genetics of Dysregulated pH Homeostasis2513121UNINA03474nam 22005415 450 991013684400332120230810144008.01-137-57673-110.1057/978-1-137-57673-6(CKB)3710000000907699(DE-He213)978-1-137-57673-6(MiAaPQ)EBC4722251(EXLCZ)99371000000090769920161015d2016 u| 0engurnn#008mamaatxtrdacontentcrdamediacrrdacarrierJapan and the Great Divergence A Short Guide /by Penelope Francks1st ed. 2016.London :Palgrave Macmillan UK :Imprint: Palgrave Macmillan,2016.1 online resource (VIII, 123 p.)Palgrave Studies in Economic History,2662-65001-137-57672-3 Includes bibliographical references at the end of each chapters and index.This text offers an accessible guide to the ways in which our growing knowledge of development in early-modern and modernising Japan can throw light on the paths that industrialisation was eventually to take across the globe. It has long been taken as read that the industrial revolution was the product of some form of ‘European superiority’ dating back to at least early-modern times. In The Great Divergence, Kenneth Pomeranz challenged this assumption on the basis of his evidence that parts of eighteenth-century China were as well placed as northern Europe to achieve sustained economic growth, thus igniting what has been called ‘the single most important debate in recent global history’. Japan, as the only non-Western country to experience significant industrialisation before the Second World War, ought to provide crucial – and intriguing – evidence in the debate, but analysis of the Japanese case in such a context has remained limited. This work suggests ways of re-interpreting Japanese economic history in the light of the debate, so arguing that global historians and scholars of Japan have in fact much to say to each other within the comparative framework that the Great Divergence provides. Penelope Francks is now Honorary Fellow of the University of Leeds, UK, where she was previously Reader in Japanese Studies and taught for many years on the history and economy of Japan and the rest of East Asia. Her research interests lie in Japanese economic history, especially rural development and, more recently, the history of consumption. She has published a range of books and journal articles on these topics. .Palgrave Studies in Economic History,2662-6500Economic historyEvolutionary economicsInstitutional economicsAsiaEconomic conditionsEconomic HistoryInstitutional and Evolutionary EconomicsAsian EconomicsEconomic history.Evolutionary economics.Institutional economics.AsiaEconomic conditions.Economic History.Institutional and Evolutionary Economics.Asian Economics.330.9Francks Penelopeauthttp://id.loc.gov/vocabulary/relators/aut124463BOOK9910136844003321Japan and the Great Divergence2289026UNINA