03094oam 2200457 450 991029833350332120190911103512.01-4614-8642-410.1007/978-1-4614-8642-8(OCoLC)865509658(MiFhGG)GVRL6XEK(EXLCZ)99371000000007338320140913d2014 uy 0engurun|---uuuuatxtccrThe genetics of obesity /Struan F.A. Grant, editor1st ed. 2014.New York :Springer,2014.1 online resource (viii, 128 pages) color illustrationsGale eBooksDescription based upon print version of record.1-4614-8641-6 Includes bibliographical references and index.Genetic Variation and Obesity Prior to the Era of Genome-Wide Association Studies -- Genetic Obesity Syndromes -- Genome-Wide Association Studies of Obesity -- Copy Number Variants and their Contribution to the Risk of Obesity -- Genetics of Childhood Obesity -- Genetic Pleiotropies of Obesity -- Functional Follow-up of Genetic Variants Using FTO as the Prime Example -- Index.In the past four years, many genetic loci have been implicated for BMI from the outcomes of genome-wide association studies (GWAS), primarily in adults. Insulin-induced gene 2 (INSIG2) was the first locus to be reported by this method to have a role in obesity, but replication attempts have yielded inconsistent outcomes. The identification of the second locus, the fat mass- and obesity-associated gene (FTO),  has been more robustly observed by others. Studies from both FTO knock out and FTO over expression mouse model support the fact that FTO is directly involved in the regulation of energy intake and metabolism in mice, where the lack of FTO expression leads to leanness while enhanced expression of FTO leads to obesity.   Along with numerous other studies, a number of genetic variants have been established robustly in the context of obesity, giving us fresh insights into the pathogenesis of the disease. This book provides a comprehensive overview of efforts aimed at uncovering genetic variants associated with obesity, which have been particularly successful in the past 5 years with the advent of genome-wide association studies (GWAS). The Genetics of Obesity covers this state of the art technology and its application to obesity in great detail. Topics include genetics of childhood obesity, genetics of syndromic obesity, copy number variants and extreme obesity, co-morbidities of obesity genetics, and functional follow-up of genetic variants.ObesityGenetic aspectsObesityGenetic aspects.599.935599935610611.01816Grant Struan F. A.MiFhGGMiFhGGBOOK9910298333503321The Genetics of Obesity2502162UNINA