01024nam0 2200289 450 00000326220090507163726.020011106d1994----km-y0itay50------baitaIT<<Il >>codice dell'ambienteillustrato con il commento, la bibliografia, la giurisprudenza e la manualistica ad uso di privati p.g. e magistraturaStefano Maglia, Maurizio Santoloci5. ed.PiacenzaLa Tribuna19942046 p.20 cm<<I >>codici illustratiSegue: appendice di aggiornamento2001<<I >>codici illustrati<<Il >>codice dell'ambiente38138Ambiente naturaleTutelaLegislazione344.4504602638Maglia,Stefano35647Santoloci,Maurizio76405ITUNIPARTHENOPERICAUNIMARC000003262PISTP1 348-C/623174320011107Codice dell'ambiente38138UNIPARTHENOPE03958nam 22006255 450 991029833280332120200705153832.03-7091-1806-910.1007/978-3-7091-1806-1(CKB)3710000000248978(EBL)1966152(OCoLC)908084961(SSID)ssj0001353663(PQKBManifestationID)11768648(PQKBTitleCode)TC0001353663(PQKBWorkID)11316872(PQKB)10768430(MiAaPQ)EBC1966152(DE-He213)978-3-7091-1806-1(PPN)181347687(EXLCZ)99371000000024897820140922d2014 u| 0engur|n|---|||||txtccrRas Superfamily Small G Proteins: Biology and Mechanisms 1 General Features, Signaling /edited by Alfred Wittinghofer1st ed. 2014.Vienna :Springer Vienna :Imprint: Springer,2014.1 online resource (447 p.)Description based upon print version of record.3-7091-1805-0 Includes bibliographical references and index at the end of each chapters.Evolution of the Ras Superfamily of GTPases -- The structure of the G domain of the Ras superfamily -- GEFs and GAPs: Mechanisms and Structures -- Bacterial protein toxins acting on small GTPases -- Posttranslational modifications of small G proteins -- Targeting the Raf-MEK-ERK Mitogen-Activates Protein Kinase Cascade for the Treatment of RAS Mutant Cancers -- RAS Genes and Cancer -- The Spatial Organization of Ras Signaling -- Ras Nanoclusters -- Mouse Models of Ras induced Tumors and Developmental Disorders -- Rap signaling -- The coordinated biology and signaling partners of Ral G-proteins -- Structure and Function of the mTOR Activator Rheb -- Classical Rho proteins: Biochemistry of molecular switch function and regulation -- Atypical Rho family members -- Molecular Structures, Cellular Functions and Physiological Roles of Rho Effectors -- Principles driving the spatial organization of Rho GTPase signaling at synapses -- Rho GTPases in Cancer.This first of two volumes provides a general overview of the genetics, structure, mechanism and regulation of the Ras superfamily proteins and describes in detail the signaling pathways and processes regulated by specific members of this family. The focus of this first volume is on the Rho and Ras subfamily of small G proteins. Renowned scientists provide insights into the biochemistry of the classical and non-classical small G-protein family members, their spatio-temporal regulation, their effectors and their roles in health and disease. Together with Volume 2, this book provides a comprehensive and state-of-the-art work on small G-proteins (GTPases). It is intended for graduates and professors in biochemistry and cell biology already working on small G-proteins (small GTPases), but also offers an extremely valuable resource for those readers who are new to the field.CytologyProteinsCell Biologyhttps://scigraph.springernature.com/ontologies/product-market-codes/L16008Protein Sciencehttps://scigraph.springernature.com/ontologies/product-market-codes/L14040Protein Structurehttps://scigraph.springernature.com/ontologies/product-market-codes/L14050Cytology.Proteins.Cell Biology.Protein Science.Protein Structure.570571.6572.6572633Wittinghofer Alfrededthttp://id.loc.gov/vocabulary/relators/edtBOOK9910298332803321Ras Superfamily Small G Proteins: Biology and Mechanisms 12513120UNINA