04324nam 22007095 450 991029832860332120200630020602.01-4614-5915-X10.1007/978-1-4614-5915-6(CKB)3710000000073787(EBL)1592631(SSID)ssj0001066565(PQKBManifestationID)11630022(PQKBTitleCode)TC0001066565(PQKBWorkID)11067902(PQKB)11094616(MiAaPQ)EBC1592631(DE-He213)978-1-4614-5915-6(PPN)176097805(EXLCZ)99371000000007378720131123d2014 u| 0engur|n|---|||||txtccrTumor Microenvironment and Cellular Stress Signaling, Metabolism, Imaging, and Therapeutic Targets /edited by Constantinos Koumenis, Ester Hammond, Amato Giaccia1st ed. 2014.New York, NY :Springer New York :Imprint: Springer,2014.1 online resource (293 p.)Advances in Experimental Medicine and Biology,0065-2598 ;772Description based upon print version of record.1-4614-5914-1 Includes bibliographical references and index.Introduction -- Hypoxia and metabolism in cancer -- Hypoxia and Regulation of Cancer Cell Stemness -- Hypoxia-mediated metastasis -- Escape Mechanisms from Antiangiogenic Therapy: An Immune Cell’s Perspective -- Hypoxic VDAC1: a potential mitochondrial marker for cancer therapy -- Hypoxia directed drug strategies to target the tumor microenvironment -- Radiotherapy and the Tumor Microenvironment: Mutual Influence and Clinical Implications -- Autophagy and cell death to target cancer cells: exploiting synthetic lethality as cancer therapeutic -- Intratumoral Hypoxia as the Genesis of Genetic Instability and Clinical Prognosis in Prostate Cancer -- miR-210: Fine-Tuning the Hypoxic Response -- The role of complement in tumor growth -- Imaging angiogenesis, inflammation and metastasis in the tumor microenvironment with magnetic resonance imaging -- Index.The collection of chapters in this proceeding volume reflects the latest research presented at the Aegean meeting on Tumor Microenvironment and Cellular Stress held in Crete in Fall of 2012. The book provides critical insight to how the tumor microenvironment affects tumor metabolism, cell stemness, cell viability, genomic instability and more. Additional topics include identifying common pathways that are potential candidates for therapeutic intervention, which will stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery.Advances in Experimental Medicine and Biology,0065-2598 ;772Cancer researchImmunologyHuman physiologyMedical microbiologyCancer Researchhttps://scigraph.springernature.com/ontologies/product-market-codes/B11001Immunologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B14000Human Physiologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B13004Medical Microbiologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B16003Cancer research.Immunology.Human physiology.Medical microbiology.Cancer Research.Immunology.Human Physiology.Medical Microbiology.616.994Koumenis Constantinosedthttp://id.loc.gov/vocabulary/relators/edtHammond Esteredthttp://id.loc.gov/vocabulary/relators/edtGiaccia Amatoedthttp://id.loc.gov/vocabulary/relators/edtAegean Meeting on the Tumor Microenvironment and Cellular Stress(1st :2012 :Crete, Greece)BOOK9910298328603321Tumor Microenvironment and Cellular Stress2503151UNINA