03572nam 22006615 450 991029832740332120200707003738.03-319-12766-710.1007/978-3-319-12766-8(CKB)3710000000315948(EBL)1965296(OCoLC)900887006(SSID)ssj0001407859(PQKBManifestationID)11727540(PQKBTitleCode)TC0001407859(PQKBWorkID)11410059(PQKB)10986971(MiAaPQ)EBC1965296(DE-He213)978-3-319-12766-8(PPN)183149491(EXLCZ)99371000000031594820141212d2014 u| 0engur|n|---|||||txtccrMolecular Mechanisms Underpinning the Development of Obesity /edited by Clévio Nóbrega, Raquel Rodriguez-López1st ed. 2014.Cham :Springer International Publishing :Imprint: Springer,2014.1 online resource (200 p.)Description based upon print version of record.3-319-12765-9 Includes bibliographical references at the end of each chapters.Challenges in understanding development of obesity -- Monogenic forms of obesity -- Heterogeneous obesity syndromes: new strategies for diagnosis -- Genetic contribution: common forms of obesity -- The role of the GWAS identified FTO locus in regulating body size and composition -- Neural vulnerability factors that increase risk for weight gain: prevention and treatment implications -- Molecular mechanisms involved in the regulation of food intake -- Epigenetics of human obesity: a link between genetics and nutrition -- MicroRNAs in obesity and metabolism -- Obesity study: animal models -- From Homo obesus to Homo diabesus: neuroadipology insight -- Obesity and type 2 diabetes.Obesity is a multi-factorial disease, in which an excess of accumulated body fat can reach levels capable of affecting health. It results from an interplay between environmental factors, eating behavior, genes, epigenetics, and neuronal stimuli. The book provides a state-of-the-art revision about the molecular mechanisms underpinning the development of obesity, reviewing the current knowledge in areas like monogenic and polygenic obesity forms, while also providing an updated view of the emerging knowledge about epigenetics, nutrigenomics, and neuronal aspects that also contribute to obesity.Human geneticsBiochemistryCell biologyHuman Geneticshttps://scigraph.springernature.com/ontologies/product-market-codes/B12008Biochemistry, generalhttps://scigraph.springernature.com/ontologies/product-market-codes/L14005Cell Biologyhttps://scigraph.springernature.com/ontologies/product-market-codes/L16008Human genetics.Biochemistry.Cell biology.Human Genetics.Biochemistry, general.Cell Biology.571.6572599935610Nóbrega Clévioedthttp://id.loc.gov/vocabulary/relators/edtRodriguez-López Raqueledthttp://id.loc.gov/vocabulary/relators/edtBOOK9910298327403321Molecular Mechanisms Underpinning the Development of Obesity2522647UNINA