04151nam 22006855 450 991029832490332120200701155739.03-642-40444-810.1007/978-3-642-40444-3(CKB)2550000001152729(EBL)1538563(SSID)ssj0001048998(PQKBManifestationID)11673216(PQKBTitleCode)TC0001048998(PQKBWorkID)11018818(PQKB)11030969(MiAaPQ)EBC1538563(DE-He213)978-3-642-40444-3(PPN)176114726(EXLCZ)99255000000115272920131018d2014 u| 0engur|n|---|||||txtccrAntimicrobial Compounds Current Strategies and New Alternatives /edited by Tomás G. Villa, Patricia Veiga-Crespo1st ed. 2014.Berlin, Heidelberg :Springer Berlin Heidelberg :Imprint: Springer,2014.1 online resource (325 p.)Description based upon print version of record.3-642-40443-X Includes bibliographical references and index.Strategies for the design and discovery of novel antibiotics using genetic engineering and genome mining -- X-ray and Neutron Scattering Foundations for the Research in Antimicrobials -- Antibacterial, Antiviral and Antifungal Activity of Essential Oils: Mechanisms and Applications -- New antimicrobial agents of plant origin -- Advances in beta-lactam antibiotics -- The Cornerstone of Nucleic Acid-affecting Antibiotics in Bacteria -- Genetic analysis and manipulation of polyene antibiotic gene clusters as a way to produce more effective antifungal compounds -- Enzybiotics: The rush towards prevention and control of multi-resistant bacteria (MRB) -- New cell wall-affecting antifungal antibiotics -- Perspectives in the research on Antimicrobial peptides -- Glycopeptides and bacterial cell walls.Since penicillin and salvarsan were discovered, a number of new drugs to combat infectious diseases have been developed, but at the same time, the number of multi-resistant microorganism strains is increasing. Thus, the design of new and effective antibacterial, antiviral and antifungal agents will be a major challenge in the next years. This book reviews the current state-of-the-art in antimicrobial research and discusses new strategies for the design and discovery of novel therapies. Topics covered include the use of genetic engineering, genome mining, manipulation of gene clusters, X-ray and neutron scattering as well as the antimicrobial effects of essential oils, antimicrobial agents of plant origin, beta-lactam antibiotics, antimicrobial peptides, and cell-wall-affecting antifungal antibiotics.MicrobiologyMedical microbiologyMicrobial geneticsMicrobial genomicsPharmaceutical technologyMicrobiologyhttps://scigraph.springernature.com/ontologies/product-market-codes/L23004Medical Microbiologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B16003Microbial Genetics and Genomicshttps://scigraph.springernature.com/ontologies/product-market-codes/L32010Pharmaceutical Sciences/Technologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B21010Microbiology.Medical microbiology.Microbial genetics.Microbial genomics.Pharmaceutical technology.Microbiology.Medical Microbiology.Microbial Genetics and Genomics.Pharmaceutical Sciences/Technology.616.90461Villa Tomás Gedthttp://id.loc.gov/vocabulary/relators/edtVeiga-Crespo Patriciaedthttp://id.loc.gov/vocabulary/relators/edtBOOK9910298324903321Antimicrobial Compounds2500527UNINA