01747nam a2200337 i 450099100233639970753620020503164217.0000908s1965 it ||| | ita b10350044-39ule_instEXGIL102277ExLBiblioteca Interfacoltàita271Leclercq, Jean<1911-1993>300104Cultura umanistica e desiderio di Dio :studio sulla letteratura monastica del Medio evo /Jean Leclercq ; prefazione di Pier Cesare BoriFirenze :Sansoni,1965VIII, 386 p., 4 tav. ;24 cm.Biblioteca storica Sansoni.N.S. ;42Tit. orig.: L'amour des lettres et le désir de Dieu.Cultura monasticaSec. 6.-12.Bori, Pier Cesare.b1035004412-10-2127-06-02991002336399707536LE002 It. XXIII A 3212002000736536le002-E0.00-l- 01010.i1041054527-06-02LE002 St. IX H 4312002000695109le002-E0.00-l- 00000.i1260386708-10-03LE002 It. XXIII A 32/bis22002000097323le002-E0.00-l- 00000.i1260387908-10-03LE009 STOR.34-97bis02009000148215le009-E0.00-l- 00000.i1113584028-06-02LE009 STOR.34-97ter02009000096882le009-E0.00-l- 02020.i1253998302-07-03LE023 Fondo Brambilla 49712023000205730le023-E28.00-no 00000.i1598028512-10-21Cultura umanistica e desiderio di Dio204566UNISALENTO(3)le002(2)le00901-01-00ma -itait 0503895nam 22006735 450 991029829650332120200706200631.03-319-18102-510.1007/978-3-319-18102-8(CKB)3710000000416706(EBL)2094800(SSID)ssj0001500649(PQKBManifestationID)11866009(PQKBTitleCode)TC0001500649(PQKBWorkID)11522404(PQKB)10400799(DE-He213)978-3-319-18102-8(MiAaPQ)EBC2094800(PPN)186026757(EXLCZ)99371000000041670620150529d2015 u| 0engur|n|---|||||txtccrHistone Recognition /edited by Ming-Ming Zhou1st ed. 2015.Cham :Springer International Publishing :Imprint: Springer,2015.1 online resource (284 p.)Description based upon print version of record.3-319-18101-7 Includes bibliographical references and index.The Bromodomain as the Acetyl-Lysine Binding Domain in Gene Transcription -- PHD Fingers as Histone Readers -- Methyl-Lysine Recognition by the Royal Family Modules: Chromo, Tudor, MBT, Chromo Barrel, and PWWP Domains -- Histone Recognition by WD40 Proteins -- Methyl-Lys Recognition by Ankyrin Repeat Proteins -- Methyl-Arginine Recognition by Tudor Domains -- Histone Recognition by Tandem Modules and Modulation by Multiple PTMs -- Genome-Wide Profiling of Molecular Recognition of Histone PTMs -- BET Bromodomain Inhibition as a Therapeutic Approach in Hematological Malignancies -- Anti-Inflammatory Effects of BET Protein Inhibition Through Modulation of Gene Transcription -- Activating Latent HIV by Inhibiting Bromodomain Proteins -- Small Molecule Modulation of Methyl-Lysine Mediated Interactions.This book provides a timely review of the role of histone modifications in epigenetic control of gene expression. Topics covered include: basic mechanisms of molecular recognition of histone post-translational modification (PTMs); combinatorial readout of histone PTMs by tandem epigenome reader domains; genome-wide profiling of histone PTM interactions; small molecule modulation of histone PTM interactions and their potential as a new approach to therapeutic intervention in human diseases. All chapters were written by leading scientists who made the original key discoveries of the structure and mechanism of evolutionarily conserved reader domains, which serve to direct gene transcription in chromatin through interactions with DNA-packing histones in a PTM-sensitive manner.Gene expressionPost-translational modificationProteinsMedical geneticsGene Expressionhttps://scigraph.springernature.com/ontologies/product-market-codes/B12010Posttranslational Modificationhttps://scigraph.springernature.com/ontologies/product-market-codes/L14090Protein-Ligand Interactionshttps://scigraph.springernature.com/ontologies/product-market-codes/L14060Gene Functionhttps://scigraph.springernature.com/ontologies/product-market-codes/B12030Gene expression.Post-translational modification.Proteins.Medical genetics.Gene Expression.Posttranslational Modification.Protein-Ligand Interactions.Gene Function.572.6610611.01816Zhou Ming-Mingedthttp://id.loc.gov/vocabulary/relators/edtBOOK9910298296503321Histone Recognition2508865UNINA