04224nam 22006615 450 991029828840332120200702023940.03-662-45024-010.1007/978-3-662-45024-6(CKB)3710000000305965(EBL)1966090(SSID)ssj0001385879(PQKBManifestationID)11767065(PQKBTitleCode)TC0001385879(PQKBWorkID)11341304(PQKB)10844756(DE-He213)978-3-662-45024-6(MiAaPQ)EBC1966090(PPN)183089715(EXLCZ)99371000000030596520141127d2015 u| 0engur|n|---|||||txtccrVaccine Analysis: Strategies, Principles, and Control /edited by Brian K. Nunnally, Vincent E. Turula, Robert D. Sitrin1st ed. 2015.Berlin, Heidelberg :Springer Berlin Heidelberg :Imprint: Springer,2015.1 online resource (669 p.)Description based upon print version of record.3-662-45023-2 Includes bibliographical references and index.Live Attenuated Viral Vaccines -- Inactivated Viral Vaccines -- Recombinant Virus Like Particle Protein Vaccines -- Analysis of influenza vaccines -- Live-attenuated and inactivated whole-cell bacterial vaccines -- Analytical control strategy of bacterial subunit vaccines -- Bacterial Polysaccharide Vaccines: Analytical Perspectives -- Glycoconjugate vaccines -- Vaccines in research and development: new production platforms and new biomolecular entities for new needs -- Role of Analytics In Viral Safety -- Deep Sequencing Applications for Vaccine Development and Safety -- Quality-by-design: As related to analytical concepts, control and qualification -- Vaccine Potency Assays -- Establishing a Shelf-life and Setting Lot-release Specifications -- Vaccine Reference Standards -- Lot Release of Vaccines by Regulatory Authorities and Harmonization of Testing Requirements -- Dendritic cell targeting vaccines.This book is an indispensable tool for anyone involved in the research, development, or manufacture of new or existing vaccines. It describes a wide array of analytical and quality control technologies for the diverse vaccine modalities. Topics covered include the application of both classical and modern bio-analytical tools; procedures to assure safety and control of cross contamination; consistent biological transition of vaccines from the research laboratory to manufacturing scale; whole infectious attenuated organisms, such as live-attenuated and inactivated whole-cell bacterial vaccines and antiviral vaccines using attenuated or inactivated viruses; principles of viral inactivation and the application of these principles to vaccine development; recombinant DNA approaches to produce modern prophylactic vaccines; bacterial subunit, polysaccharide and glycoconjugate vaccines; combination vaccines that contain multiple antigens as well as regulatory requirements and the hurdles of licensure.VaccinesImmunologyMedical biochemistryVaccinehttps://scigraph.springernature.com/ontologies/product-market-codes/B16010Immunologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B14000Medical Biochemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/H35005Vaccines.Immunology.Medical biochemistry.Vaccine.Immunology.Medical Biochemistry.610612015615372616079Nunnally Brian Kedthttp://id.loc.gov/vocabulary/relators/edtTurula Vincent Eedthttp://id.loc.gov/vocabulary/relators/edtSitrin Robert Dedthttp://id.loc.gov/vocabulary/relators/edtBOOK9910298288403321Vaccine Analysis: Strategies, Principles, and Control2500507UNINA