03584nam 22007575 450 991029827210332120230810184149.03-319-13725-510.1007/978-3-319-13725-4(CKB)3710000000329733(EBL)1966005(OCoLC)900639416(SSID)ssj0001424497(PQKBManifestationID)11891907(PQKBTitleCode)TC0001424497(PQKBWorkID)11362919(PQKB)10923311(DE-He213)978-3-319-13725-4(MiAaPQ)EBC1966005(PPN)183520467(EXLCZ)99371000000032973320150102d2015 u| 0engur|n|---|||||txtccrIgE Antibodies: Generation and Function /edited by Juan J. Lafaille, Maria A. Curotto de Lafaille1st ed. 2015.Cham :Springer International Publishing :Imprint: Springer,2015.1 online resource (157 p.)Current Topics in Microbiology and Immunology,2196-9965 ;388Description based upon print version of record.3-319-13724-7 Includes bibliographical references and index.Biology of IgE Production: IgE Cell Differentiation and the Memory of IgE Responses -- Molecular Mechanisms of IgE Class Switch Recombination -- Anti-IgE Therapy: Clinical Utility and Mechanistic Insights -- New Insights on the Signaling and Function of the High Affinity Receptor for IgE -- Helminth-Induced IgE and Protection Against Allergic Disorders -- IgE Immunotherapy Against Cancer.This volume examines all facets of the complex biology of Immunoglobulin E (IgE) antibodies, which play an essential role in the pathophysiology of allergic diseases and immunity to parasites. It highlights the unique mechanisms involved in the regulation of IgE production at both the molecular and cellular level. Furthermore, it discusses in detail novel findings on how the affinity, specificity and cross-reactivity of IgE can fine-tune mast cell responses to allergens. The book also explores the beneficial roles of IgE antibodies in immunity to helminthes and protection against tumors, and how the properties of IgE-mediated immunity are employed in the development of IgE therapeutic antibodies. All chapters were written by respected experts in their fields and will appeal to scientists and clinicians alike.Current Topics in Microbiology and Immunology,2196-9965 ;388ImmunospecificityMedicineResearchBiologyResearchAllergyParasitologyAdaptive ImmunityBiomedical ResearchAllergologyParasitologyImmunospecificity.MedicineResearch.BiologyResearch.Allergy.Parasitology.Adaptive Immunity.Biomedical Research.Allergology.Parasitology.616.0795Lafaille Juan Jedthttp://id.loc.gov/vocabulary/relators/edtCurotto de Lafaille Maria Aedthttp://id.loc.gov/vocabulary/relators/edtMiAaPQMiAaPQMiAaPQBOOK9910298272103321IgE Antibodies: Generation and Function2499272UNINA