04911nam 22007215 450 991029826400332120200706015135.094-017-7197-910.1007/978-94-017-7197-9(CKB)3710000000454041(EBL)3567941(SSID)ssj0001534792(PQKBManifestationID)11995416(PQKBTitleCode)TC0001534792(PQKBWorkID)11497722(PQKB)11753140(DE-He213)978-94-017-7197-9(MiAaPQ)EBC3567941(PPN)187689776(EXLCZ)99371000000045404120150728d2015 u| 0engur|n|---|||||txtccrNeuronal Tissue-Nonspecific Alkaline Phosphatase (TNAP) /edited by Caroline Fonta, László Négyessy1st ed. 2015.Dordrecht :Springer Netherlands :Imprint: Springer,2015.1 online resource (401 p.)Subcellular Biochemistry,0306-0225 ;76Description based upon print version of record.94-017-7196-0 Includes bibliographical references at the end of each chapters and index.1 Clinical forms and animal models of hypophosphatasia -- 2 Molecular genetics of hypophosphatasia and phenotype-genotype correlations -- 3 Genetically modified mice for studying TNAP function -- 4 Tissue-Nonspecific Alkaline Phosphatase in the Developing Brain and in Adult Neurogenesis -- 5 Rediscovering TNAP in the brain: a major role in regulating the function and development of the cerebral cortex -- 6 TNAP in the retina -- 7 Tissue Non-specific Alkaline Phosphatase (TNAP) in vessels of the brain -- 8 What can we learn about the neural functions of TNAP from studies on other organs and tissues? -- 9 TNAP, an essential player in membrane lipid rafts of neuronal cells -- 10 Signal transduction pathways of TNAP: molecular network analyses -- 11 Vitamin B-6 Metabolism and Interactions with TNAP -- 12 Tetramisole and levamisole suppress neuronal activity independently from their inhibitory action on Tissue Non-Specific Alkaline Phosphatase in mouse cortex -- 13 TNAP and Pain Control -- 14 Neurological symptoms of Hypophosphatasia -- 15 Recombinant enzyme replacement therapy in hypophosphatasia -- 16 Neurogenetic Aspects of Hyperphosphatasia in Mabry Syndrome -- 17 The role of tissue non-specific alkaline phosphatase (TNAP) in Neurodegenerative diseases: Alzheimer’s disease in the focus -- 18 TNAP plays a key role in neural differentiation as well as in neurodegenerative disorders -- Index.Phosphatases such as TNAP are fundamental in regulating cellular, and consequently numerous body functions. TNAP is a ubiquitous enzyme with a wide spectrum of substrates and specificity regulation at the cellular level and the lack of TNAP activity is a lethal condition. Recent findings of a highly specific regional, laminar and subcellular localization of TNAP in the cerebral cortex indicates that in addition to its metabolic and skeletal functions, TNAP also plays a role in regulating cerebral functions, most probably cognition. In fact, TNAP disturbance could result in complex diseases such as epilepsy, developmental retardation and Alzheimer disease. Available data suggest that, regarding brain functions, TNAP is a potentially important target of clinical research. The proposed book aims to provide an overview of our current understanding of the functions of TNAP in the brain.Subcellular Biochemistry,0306-0225 ;76Human physiologyAnimal physiologyDevelopmental biologyNeurosciencesHuman Physiologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B13004Animal Physiologyhttps://scigraph.springernature.com/ontologies/product-market-codes/L33030Developmental Biologyhttps://scigraph.springernature.com/ontologies/product-market-codes/L18000Neuroscienceshttps://scigraph.springernature.com/ontologies/product-market-codes/B18006Human physiology.Animal physiology.Developmental biology.Neurosciences.Human Physiology.Animal Physiology.Developmental Biology.Neurosciences.574.19253Fonta Carolineedthttp://id.loc.gov/vocabulary/relators/edtNégyessy Lászlóedthttp://id.loc.gov/vocabulary/relators/edtMiAaPQMiAaPQMiAaPQBOOK9910298264003321Neuronal Tissue-Nonspecific Alkaline Phosphatase (TNAP)2538502UNINA