01049nam0 2200301 450 991029505920332120181212145420.020181212d1992----km y0itay50 bagerDEa 001yy<<Die >>hochmittelalterliche Anna-Selbdritt-Gruppe[Herbert Beck]Städtische Galerie Liebighaus, Museum alter Plastik Frankfurt am MainMainzSchmidt199231 p.ill.27 cmPatrimoniaKulturstiftung der Länder0941-703635Sul front.: Hessische KulturstiftungScultura lignea gotica734.2522itaBeck,Herbert86387Städtische Galerie Liebieghaus<Frankfurt am Main>Museum alter Plastik<Frankfurt am Main>ITUNINAREICATUNIMARCBK9910295059203321734.25 BEC 1bibl. 2018FLFBCFLFBCHochmittelalterliche Anna-Selbdritt-Gruppe1540299UNINA00922cam2-2200289---450 99000242695020331620220601115138.0000242695USA01000242695(ALEPH)000242695USA0100024269520050601d1977----km-y0itay50------baitaITaf||||||001yy3: Dalla dominazione aragonese (1442) al Viceregno (1734)Giuseppe BrasacchioChiaravalle CentraleEffe Emme1977364 p., [5] carte geografiche24 cm0010002426892001Storia economica della CalabriaBRASACCHIO,Giuseppe133855ITsalbcISBD990002426950203316X.4. 102 3(III 6 84/3)651/3 DSSSX.4.00350909BKUMA3.: Dalla dominazione aragonese (1442) al Viceregno (1734607029UNISA04883nam 22007815 450 991080619860332120240313004255.03-031-30023-810.1007/978-3-031-30023-3(PPN)27543219X(CKB)30119387000041(DE-He213)978-3-031-30023-3(MiAaPQ)EBC31095553(Au-PeEL)EBL31095553(EXLCZ)993011938700004120240129d2024 u| 0engur|||||||||||txtrdacontentcrdamediacrrdacarrierPharmaceutical Biotechnology Fundamentals and Applications /edited by Daan J. A. Crommelin, Robert D. Sindelar, Bernd Meibohm6th ed. 2024.Cham :Springer International Publishing :Imprint: Springer,2024.1 online resource (XXV, 682 p. 259 illus., 245 illus. in color.)9783031300226 Includes bibliographical references and index.Molecular Biotechnology -- Biophysical and biochemical analysis of recombinant proteins -- Production and downstream processing of biotech products -- Formulation of biotech products, including biopharmaceutical considerations -- Pharmacokinetics and pharmacodynamics of peptide and protein drugs -- Immunogenicity of pharmaceutical proteins -- General considerations of monoclonal antibodies from structure to therapeutic application -- Genomics, Other “Omics” Technologies, Personalized Medicine and Additional Biotechnology-Related Techniques -- Dispensing biotechnology products: handling, professional education and product information -- Economic considerations in medical biotechnology -- Regulatory framework for biosimilars -- Vaccines -- Oligonucleotides and siRNA -- Gene therapy -- Stem cell technology -- Therapeutic Applications.-Endocrinology -- Insulin -- Follicle-stimulating hormone -- Growth hormone -- Cardiovascular and Respiratory Applications -- Recombinant coagulation factors and thrombolytics -- Recombinant human deoxyribonuclease -- Oncology -- Monoclonal antibodies in oncology -- Hematopoetic growth factors -- Inflammation and Immunemodulation -- Monoclonal antibodies in transplantation -- Monoclonal antibodies and antibody-based therapeutics in anti-inflammatory therapy -- Interferons and interleukins -- Anti-infectious diseases -- Monoclonal antibodies -- Enzyme replacement therapy.This introductory text explains both the basic science, production, quality, dosage forms, administration, economic and regulatory aspects and the clinical applications of biotechnology-derived pharmaceuticals. It serves as a complete one-stop source for undergraduate/graduate pharmacists and pharmaceutical science students. An additional important audience are pharmaceutical scientists in industry and academia, particularly those who have not received formal training in pharmaceutical biotechnology and are inexperienced in this field. The rapid growth and advances in the field made it necessary to revise this textbook in order to continue providing up-to-date information and introduce readers to cutting edge knowledge and technology of this field. This Sixth Edition completely updates the previous edition and includes additional coverage on new approaches such as oligonucleotides, siRNA, mRNA, gene therapy, cell therapies, monoclonal antibodies and vaccines. With more than 3-million-chapter downloads, the fifth edition of the textbook has achieved widespread distribution as a key educational resource for the field of pharmaceutical biotechnology.Pharmaceutical chemistryBiotechnologyPharmacologyMedicineResearchBiologyResearchDrug delivery systemsBiologicalsBiopharmaceuticsPharmaceuticsBiotechnologyPharmacologyBiomedical ResearchDrug DeliveryBiologicsPharmaceutical chemistry.Biotechnology.Pharmacology.MedicineResearch.BiologyResearch.Drug delivery systems.Biologicals.Biopharmaceutics.Pharmaceutics.Biotechnology.Pharmacology.Biomedical Research.Drug Delivery.Biologics.615.19Crommelin D. J. A(Daan J. A.),Sindelar Robert D.Meibohm BerndMiAaPQMiAaPQMiAaPQBOOK9910806198603321Pharmaceutical biotechnology57094UNINA