05587nam 2200505 450 991027100820332120170816132404.01-119-38440-01-119-38442-71-119-38443-5(CKB)3710000001633585(DLC) 2017022128(MiAaPQ)EBC4914178(EXLCZ)99371000000163358520170811h20172017 uy 0engur|||||||||||txtrdacontentnrdamediancrdacarrierAnalytical characterization of biotherapeutics /edited by Jennie R. Lill, Wendy N. SandovalHoboken, New Jersey :Wiley,2017.©20171 online resource1-119-05310-2 Includes bibliographical references at the end of each chapters and index.Machine generated contents note: Dedication Chapter 1: Introduction to Biotherapeutics Jennie R. Lill Chapter 2: Mass Spectrometric Characterization of Recombinant Proteins Corey E Bakalarski, Wendy N Sandoval & Jennie R Lill Chapter 3: Characterizing the Termini of Recombinant Proteins Nestor Solis, Christopher M. Overall Chapter 4: Assessing activity & conformation of recombinant proteins Diego Ellerman, Till Maurer, Justin M. Scheer Chapter 5: Structural Characterization of Recombinant Proteins & Antibodies Paola Di Lello and Patrick Lupardus Chapter 6: Antibody de novo sequencing Natalie Castellana, Adrian Guthals Chapter 7: Characterization of Antibody Drug Conjugates Yichin Liu Chapter 8: Characterization of Bi-Specific or other Hybrid molecules T. Noelle Lombana and Christoph Spiess Chapter 9: Bio-Repository Anne Baldwin, Kurt Schroeder, Lovejit Singh, Karen Billeci Chapter 10: Characterization of Manufacturing Host-Cell Contaminant Proteins Denise Krawitz, Jason Rouse, Justin Sperry, Wendy Sandoval, Martin Vanderlaan Chapter 11: Analytical Tools for Biologics Molecular Assessment Wilson Phung , Wendy Sandoval, Robert F Kelley & Jennie R Lill Chapter 12: Glycan Characterization: Determining the Structure, Distribution, and Localization of Glycoprotein Glycans John Briggs INDEX."The definitive guide to the myriad analytical techniques available to scientists involved in biotherapeutics research Analytical Characterization of Biotherapeutics covers all current and emerging analytical tools and techniques used for the characterization of therapeutic proteins and antigen reagents. From basic recombinant antigen and antibody characterization, to complex analyses for increasingly complex molecular designs, the book explores the history of the analysis techniques and offers valuable insights into the most important emerging analytical solutions. In addition, it frames critical questions warranting attention in the design and delivery of a therapeutic protein, exposes analytical challenges that may occur when characterizing these molecules, and presents a number of tested solutions. The first single-volume guide of its kind, Analytical Characterization of Biotherapeutics brings together contributions from scientists at the leading edge of biotherapeutics research and manufacturing. Key topics covered in-depth include the structural characterization of recombinant proteins and antibodies, antibody de novo sequencing, characterization of antibody drug conjugates, characterization of bi-specific or other hybrid molecules, characterization of manufacturing host-cell contaminant proteins, analytical tools for biologics molecular assessment, and more. Each chapter is written by a recognized expert or experts in their field who discuss current and cutting edge approaches to fully characterizing biotherapeutic proteins and antigen reagents Covers the full range of characterization strategies for large molecule based therapeutics Provides an up-to-date account of the latest approaches used for large molecule characterization Chapters cover the background needed to understand the challenges at hand, solutions to characterize these large molecules, and a summary of emerging options for analytical characterization, Analytical Characterization of Biotherapeutics is an up-to-date resource for analytical scientists, biologists, and mass spectrometrists involved in the analysis of biomolecules, as well as scientists employed in the pharmaceuticals and biotechnology industries. Graduate students in biology and analytical science, and their instructors will find it to be fascinating and instructive supplementary reading.--Provided by publisher."This book covers all current and emerging analytical tools and techniques used for the characterization of therapeutic proteins and antigen reagents. From basic recombinant antigen and antibody characterization, to complex analyses for increasingly complex molecular designs, the book explores the history of the analysis techniques and offers valuable insights into the most important emerging analytical solutions"--Provided by publisher.ProteinsTherapeutic useProteinsAnalysisElectronic books.ProteinsTherapeutic use.ProteinsAnalysis.615.7SCI013010bisacshLill Jennie R.Sandoval Wendy N.MiAaPQMiAaPQMiAaPQBOOK9910271008203321Analytical characterization of biotherapeutics2794421UNINA01009nam a2200277 i 4500991001621099707536120301s2011 enk b 001 0 eng 9780415365802 b14043300-39ule_instFacoltà SSPTita320.8522Parker, Simon,1964-476641Cities, politics, and power /by Simon ParkerMilton Park, Abingdon, Oxon, [England] ;New York :Routledge,c2011xii, 211 p. :ill. ;24 cmCritical Introduction to Urbanism and the CityCon bibliografiaCittà e poterePotere localeUrbanesimo.b1404330002-04-1401-03-12991001621099707536LE021 320.85 PAR01.0112020000038627le021pE31.38-n- 00000.i1538704501-03-12Cities, politics, and power244873UNISALENTOle02001-03-12ma -engenk0002027ngm 2200421 a 450 991088785590332120231116231049.0(CKB)3780000000052273(UkLU-K)001103508(UkLoHST)1260(UkLoHST)HST2045_1_2(UkLoHST)HS-2045_1_2(EXLCZ)9937800000000522732045Henry Stewart Talks20080121d2009 || vengurcna|||a||||crdamediacrrdacarrierCentrosome duplication and separation in animal cells /Andrew M. FryLondon Henry Stewart Talks20091 online resource (1 streaming video file (33 min.) color, sound)The cell division cycle : controlling when and where cells divide and differentiate,2056-452XAnimated audio-visual presentation with synchronized narration.Title from title frames.Contents: The centrosome as a microtubule organizing centre -- Microtubule nucleation -- Mitotic spindle organization -- Centrosomes and ciliogenesis -- Centrosome structure and composition -- The centrosome duplication cycle -- Regulation of centrosome duplication -- Centriole formation pathways -- Centriolar cohesion -- Regulation of centrosome separation -- Centrosome overduplication in cancer cells -- Aneuploidy and chromosome instability -- Models for the acquisition of supernumerary centrosomes.Henry Stewart talks.Biomedical & life sciences collection.Cell division cycle : controlling when and where cells divide and differentiate.Cell CycleGenes, cdcCell Cycle.Genes, cdc.Fry Andrew M.(University of Leicester, UK)spk1770183UkLU-KUkLU-KVIDEO9910887855903321Centrosome duplication and separation in animal cells4248310UNINA