03135nam 2200397z- 450 991026114530332120210212(CKB)4100000002484639(oapen)https://directory.doabooks.org/handle/20.500.12854/62228(oapen)doab62228(EXLCZ)99410000000248463920202102d2017 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierViral Interactions with the NucleusFrontiers Media SA20171 online resource (124 p.)Frontiers Research Topics2-88945-247-6 Viruses cause numerous medically important diseases, affecting developing, developed, rich and poor alike. The diseases vary in severity, including chickenpox, smallpox, influenza, shingles, herpes, rabies, polio, Ebola, hanta fever, AIDS and the common cold, amongst others. Regardless of the type of tissue or organ affected, all viruses follow the same basic steps to infect host cells. Once in contact with host cells viruses release their genetic material into the cell followed by genome replication, production of viral proteins, assembly of the virus particle and egress from the infected cell. Viruses disrupt normal host cell processes in order to facilitate their own replication/assembly by re-directing cellular machinery for viral transcription, translation, assembly, release and by inhibiting antiviral responses. Regulated nuclear transport of macromolecules through the nuclear pore complex, the only means of transport across the nuclear membrane, is essential for normal cell function and an effective antiviral response. Many viruses disrupt or exploit the nucleocytoplasmic trafficking pathways in host cells. Cytoplasmic viruses exploit the host cell nucleocytoplasmic trafficking machinery to access nuclear functions and/or disrupt nuclear transport, while several DNA viruses use the trafficking pathways to enable export of their components into the cytoplasm; yet others complete their assembly within the nucleus and use nuclear export pathways to access the cytoplasm. Indeed, the many and varied interactions of viruses and viral proteins with nucleocytoplasmic trafficking components have been invaluable in pathway discovery. Importantly, mounting evidence suggests that these interactions play essential roles in virus replication/assembly and hence may be key to understanding pathophysiology of viral diseases. This Frontiers Research Topic is dedicated to the importance of nucleocytoplasmic trafficking to viral pathogenesis.Microbiology (non-medical)bicsscDNA Virusesnuclear pore complexnuclear transportRNA Virusesviral nuclear interactionsMicrobiology (non-medical)Erin Joanne Walkerauth1326356Reena GhildyalauthBOOK9910261145303321Viral Interactions with the Nucleus3037369UNINA02244nam 2200481z- 450 991034673930332120210212(CKB)4920000000094321(oapen)https://directory.doabooks.org/handle/20.500.12854/58618(oapen)doab58618(EXLCZ)99492000000009432120202102d2018 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierThe Roles of GnIH in Reproductive Function and BehaviorFrontiers Media SA20181 online resource (128 p.)Frontiers Research Topics2-88945-442-8 Since the discovery of gonadotropin-releasing hormone (GnRH) at the beginning of 1970s, it has been believed that GnRH is the only hypothalamic neuropeptide that regulates gonadotropin release in vertebrates. In 2000, however, a novel hypothalamic neuropeptide that actively inhibits gonadotropin release was discovered in Japanese quail and termed gonadotropin-inhibitory hormone (GnIH). Following seventeen years of research has revealed that GnIH is highly conserved across vertebrates including humans, and GnIH is involved in a number of physiological and behavioral functions related to reproduction. The aim of this e-book is to celebrate the discovery of GnIH and the progress of GnIH research by collecting review and original articles from leading scientists in this new research field.Medicinebicsscestradiolfollicle-stimulating hormonegonadotropin-inhibitory hormonegonadotropin-releasing hormonehypothalamic-pituitary-gonadal axiskisspeptinluteinizing hormonemelatoninreproductiontestosteroneMedicineTakayoshi Ubukaauth1328737Kazuyoshi TsutsuiauthLance J KriegsfeldauthIshwar ParharauthBOOK9910346739303321The Roles of GnIH in Reproductive Function and Behavior3038885UNINA