01952nam 2200373 450 99627829090331620231206213922.00-7381-9983-410.1109/IEEESTD.2015.7363716(CKB)3710000000553825(NjHacI)993710000000553825(EXLCZ)99371000000055382520231206d2015 uy 0engur|||||||||||txtrdacontentcrdamediacrrdacarrierIEEE Std 1707-2015 IEEE Recommended Practice for the Investigation of Events at Nuclear Facilities /Institute of Electrical and Electronics EngineersPiscataway, New Jersey :IEEE,2015.1 online resource (37 pages)Common terminology and recommended practices for initiating and conducting event investigations, analyzing data, producing results, and identifying corrective actions associated with facility personnel, processes, equipment, and systems at nuclear facilities are provided in this document. The scope of event investigation activities addressed includes, but is not limited to, root cause analysis, which is an in depth investigation process used to identify primary causes of an event based on the systematic and consistent use of analysis tools. This recommended practice can be used for the investigation of all events and allows the use of a graduated approach to the depth of the investigation based upon the event significance.IEEE Std 1707-2015Electric power systemsMathematical modelsElectric power systemsReliabilityElectric power systemsMathematical models.Electric power systemsReliability.621.31015118NjHacINjHaclDOCUMENT996278290903316IEEE Std 1707-20153646512UNISA03157nam 2200445z- 450 991026114230332120210211(CKB)4100000002484669(oapen)https://directory.doabooks.org/handle/20.500.12854/49990(oapen)doab49990(EXLCZ)99410000000248466920202102d2017 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierImmunomodulatory Effects of Drugs for Treatment of Immune-Related DiseasesFrontiers Media SA20171 online resource (108 p.)Frontiers Research Topics2-88945-288-3 More than 90% of diseases possess immunological abnormalities. Disorders such as inflammation, hypersensitivity, autoimmunity and immunodeficiency are simple examples of how the immune system misinterprets its surroundings and goes awry. Multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel diseases, among many others are manifestations of immune cells attacking normal tissues. On the other hand, damping the immune system leads to diseases such as cancer, AIDS, and severe combined immunodeficiency. The last ten years witnessed an explosion in developing drugs that target the immune system. Several novel monoclonal antibodies have been approved for treatment of various diseases confirming that personalized medicine approach is robust in combating diseases. Hence, the future holds great promise for using personalized and targeted medicine rather than generalized medications that, in most circumstances, proven to be ineffective and characteristically exert side effects. Approaches such as generating novel adjuvants that can stimulate the immune system without harmful side effects, targeting inflammatory cytokines and chemokines, harnessing and activating innate immune cells such as natural killer cells or dendritic cells, are examples of future approaches to treat autoimmune diseases, AIDS, and various forms of cancer resulting from chronic inflammation. More recently, targeting immune checkpoint molecules have shown therapeutic response against lung cancer and melanoma. Identifying molecules involved in autophagy is another example of how personalized medicine might help treat patients with refractory asthma and autoimmune diseases. This topic introduces the reader to these novel approaches of manipulating the immune system and developing targeted therapeutic strategies for treatment of various diseases.Medicine and NursingbicsscAdjuvantsAIDSAutophagyCancerChemokinesDrugsLeukemiaLymphomaMultiple sclerosisNK cellsMedicine and NursingAzzam A. Maghazachiauth1306124BOOK9910261142303321Immunomodulatory Effects of Drugs for Treatment of Immune-Related Diseases3028289UNINA