02355nam 2200433z- 450 991026113770332120231214133127.0(CKB)4100000002484715(oapen)https://directory.doabooks.org/handle/20.500.12854/53610(EXLCZ)99410000000248471520202102d2017 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMitogen Activated Protein KinasesFrontiers Media SA20171 electronic resource (163 p.)Frontiers Research Topics2-88945-339-1 Mitogen-activated protein kinase (MAPK) pathways are evolutionarily conserved in all eukaryotes and allow cells to respond to changes in the physical and chemical properties of the environment and to produce an appropriate response by altering many cellular functions. MAPKs are among the most intensively studied signal transduction systems. MAPK research is a very dynamic field in which new perspectives are continuously opening to the scientific community. Importantly, many MAPK inhibitors have been developed during the last years and are currently being tested in preclinical and clinical assays for inflammatory diseases and cancer treatment. In this research topic, we have gathered 14 papers covering recent advances in different aspects of the MAPK research area that have provided valuable insight into the spatiotemporal dynamics, the regulation and functions of MAPK pathways, as well as their therapeutic potential. We hope that this Research Topic helps readers to have a better understanding of the progresses that have been made recently in the field of MAPK signalling. A deeper understanding of the these pathways will facilitate the development of innovative therapeutic approaches.kinasecell differentiationp38MSKscaffoldinflammationJNKcancerMAPKERKJose Lozanoauth1317891Jose M. LizcanoauthAna CuendaauthBOOK9910261137703321Mitogen Activated Protein Kinases3033059UNINA