02058nam 2200457z- 450 991026113430332120210211(CKB)4100000002484749(oapen)https://directory.doabooks.org/handle/20.500.12854/53417(oapen)doab53417(EXLCZ)99410000000248474920202102d2017 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMicroenvironment-Derived Stem Cell PlasticityFrontiers Media SA20171 online resource (114 p.)Frontiers Research Topics2-88945-344-8 Plasticity is the hallmark of stem cells. At the same time, stem cells, like any other cell type, are influenced by their microenvironment and respond to it accordingly. A specific microenvironment is defined by a variety of factors, including biological and chemical factors, cell-cell interactions, but also metabolic and mechanical cues. Such dynamic and specialized microenvironment where the stem cells reside is considered a stem cell niche. Tissue injury as well as malignant tissue alterations lead to changes in the niche influencing the plasticity and biology of residing stem cells. Similarly, the niche changes upon tissue damage, which eventually induces differentiation of stem cells and ultimately regeneration of the tissue.Medicinebicsscextracellular vesicles (EVs)imagingimmunomodulationmicroenvironmentoxygen tensionplasticitystem cellstissue regenerationMedicineMarietta Herrmannauth1331054Slavko MojsilovicauthJelena KrsticauthIvana GadjanskiauthBOOK9910261134303321Microenvironment-Derived Stem Cell Plasticity3040079UNINA