02203nam 2200433z- 450 991026113260332120231214133236.0(CKB)4100000002484760(oapen)https://directory.doabooks.org/handle/20.500.12854/53828(EXLCZ)99410000000248476020202102d2017 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMolecular Chaperones and NeurodegenerationFrontiers Media SA20171 electronic resource (180 p.)Frontiers Research Topics2-88945-342-1 Molecular chaperones or heat-shock proteins (HSPs) play essential roles in safeguarding structural stability and preventing misfolding and aggregation of proteins, and maintaining the proteome functionality in the cell. For over two decades until the present time, new functions have been discovered and several molecular mechanisms have been elucidated for many chaperones, while the field is being continuously challenged by new open questions. Probably as a consequence of the increasing research on the molecular bases of neurodegenerative diseases, and the realisation that many such disorders are linked to protein misfolding processes, unleashing the roles and mechanisms of chaperones in the context of neurodegeneration has become a prime scientific goal. This e-book contains a diversity of reviews, perspective and original research articles highlighting the importance and potential of this emerging subject.molecular chaperonetherapeuticsneurodegenerative diseaseheat-shock responseprotein misfoldingneuroprotectionneurodegenerationheat-shock proteinproteostasisamyloid proteinCintia Roodveldtauth1320418Janice E. BraunauthTiago F. OuteiroauthBOOK9910261132603321Molecular Chaperones and Neurodegeneration3034283UNINA