02288nam 2200469z- 450 991026113260332120210211(CKB)4100000002484760(oapen)https://directory.doabooks.org/handle/20.500.12854/53828(oapen)doab53828(EXLCZ)99410000000248476020202102d2017 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMolecular Chaperones and NeurodegenerationFrontiers Media SA20171 online resource (180 p.)Frontiers Research Topics2-88945-342-1 Molecular chaperones or heat-shock proteins (HSPs) play essential roles in safeguarding structural stability and preventing misfolding and aggregation of proteins, and maintaining the proteome functionality in the cell. For over two decades until the present time, new functions have been discovered and several molecular mechanisms have been elucidated for many chaperones, while the field is being continuously challenged by new open questions. Probably as a consequence of the increasing research on the molecular bases of neurodegenerative diseases, and the realisation that many such disorders are linked to protein misfolding processes, unleashing the roles and mechanisms of chaperones in the context of neurodegeneration has become a prime scientific goal. This e-book contains a diversity of reviews, perspective and original research articles highlighting the importance and potential of this emerging subject.Neurosciencesbicsscamyloid proteinheat-shock proteinheat-shock responsemolecular chaperoneneurodegenerationneurodegenerative diseaseneuroprotectionprotein misfoldingproteostasistherapeuticsNeurosciencesCintia Roodveldtauth1320418Janice E. BraunauthTiago F. OuteiroauthBOOK9910261132603321Molecular Chaperones and Neurodegeneration3034283UNINA