05297nam 2201429z- 450 991063999670332120231214132843.03-0365-6099-8(CKB)5470000001633386(oapen)https://directory.doabooks.org/handle/20.500.12854/95875(EXLCZ)99547000000163338620202301d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMicro/Nanofluidic and Lab-on-a-Chip Devices for Biomedical ApplicationsBaselMDPI - Multidisciplinary Digital Publishing Institute20221 electronic resource (232 p.)3-0365-6100-5 Recently, microfluidic, nanofluidic and lab-on-a-chip devices have gained particular attention in biomedical applications. Due to their advantages, such as miniaturization, versatility, ease of use, cost-effectiveness, and the potential to replace animal models for drug development and testing, these devices hold tremendous potential to revolutionize the research of more effective treatments for several diseases that threaten human life. With integrated biosensors, these devices allow the development and design of micro- and nanoparticles to be studied in detail, modelling human physiology, investigating the molecular and cellular mechanisms underlying disease formation and progression, and gaining insights into the performance and long-term effects of responsive drug delivery nanocarriers. This Special Issue gathered research papers, and review articles focusing on novel microfluidic, nanofluidic and lab-on-a-chip devices for biomedical applications, addressing all steps related to fabrication, biosensor integration and development, characterization, numerical simulations and validation of the devices, optimization and, the translation of these devices from research labs to industry settings.Medicinebicsscprotein biomarkermicroarraymicrofluidic cassettemultiplex measurementimmunoassaypoint-of-care testingmicrofluidic devicesmall intestineex vivohistologyembedded resinsectioningpeptide biosensorlab-on-a-chiplabel-free detectionpeptide aptamersprotein biomarkersmicrofluidic biochiptroponin Tcomputational simulationsdrug discoveryorgan-on-a-chipmicrofluidic devicespreclinical modelsnumerical simulationsautomationnon-enzymaticDNA amplificationL-DNAmicrofluidicfluorescencepaper microfluidicssweatsensinghydrogelslactateosmotic pumpingevaporationcapillarywickingbiochemical assaymicrofluidicscell trapRBCevolutionary algorithmgenerative designartificial intelligenceorgan-on-chipliver-on-chipliver diseasemulti-level microfluidic devicelive cell imaginglong-term microscopy imagingfocus driftingimmersion oil viscositybacterial population dynamicssingle-cell studiesE. colimother machinecomputational fluid dynamicscancer-on-chipxenograftcolorectal cancerpharmacodynamicspharmacokineticsdrug efficacyoxaliplatinmicrofabricationmicrophysiological systembiophysical stimulibiochemical stimuliin vitro cell culturecortical neuronshippocampal neuronselectrical stimulationMicro-Electrode Arraysengineered neuronal networkspolydimethylsiloxanemicrochannelsin vivo micro bioreactoradditive manufacturingpoly-(ethylene glycol)-diacrylatebiocompatibilityCOVID-19diagnosisimage analysisPCRSARS-CoV-2MedicineCarvalho Violetaedt1302053Teixeira Senhorinha de Fátima Capela FortunasedtRibeiro JoãoedtCarvalho VioletaothTeixeira Senhorinha de Fátima Capela FortunasothRibeiro JoãoothBOOK9910639996703321Micro3026065UNINA03211nam 22007575 450 991025742420332120250730103237.03-540-48354-310.1007/3-540-48354-3(CKB)1000000000778094(SSID)ssj0000326776(PQKBManifestationID)12081518(PQKBTitleCode)TC0000326776(PQKBWorkID)10312646(PQKB)11594075(DE-He213)978-3-540-48354-0(MiAaPQ)EBC3072560(MiAaPQ)EBC6486303(PPN)155198807(EXLCZ)99100000000077809420121227d1999 u| 0engurnn|008mamaatxtccrSpacetime Foundations of General Relativity and Differential Geometry /by Marcus Kriele1st ed. 1999.Berlin, Heidelberg :Springer Berlin Heidelberg :Imprint: Springer,1999.1 online resource (XIX, 436 p.) Lecture Notes in Physics Monographs ;59Bibliographic Level Mode of Issuance: Monograph3-540-66377-0 Includes bibliographical references and index.Local theory of space and time -- Analysis on manifolds -- Space and time from a global point of view -- Pseudo-Riemannian manifolds -- General relativity -- Robertson-Walker cosmology -- Spherical symmetry -- Causality -- Singularity theorems.This textbook is for mathematicians and mathematical physicists and is mainly concerned with the physical justification of both the mathematical framework and the foundations of the theory of general relativity. Previous knowledge of the relevant physics is not assumed. This book is also suitable as an introduction to pseudo-Riemannian geometry with emphasis on geometrical concepts. A significant part of the text is devoted to the discussion of causality and singularity theorems. The insights obtained are applied to black hole astrophysics, thereby making the connection to current active research in mathematical physics and cosmology.Lecture Notes in Physics Monographs ;59AstrophysicsGravitationAstronomyMathematical physicsGeometry, DifferentialAstrophysicsClassical and Quantum GravityAstronomy, Cosmology and Space SciencesMathematical Methods in PhysicsDifferential GeometryAstrophysics.Gravitation.Astronomy.Mathematical physics.Geometry, Differential.Astrophysics.Classical and Quantum Gravity.Astronomy, Cosmology and Space Sciences.Mathematical Methods in Physics.Differential Geometry.530.11Kriele Marcus1962-62318MiAaPQMiAaPQMiAaPQBOOK9910257424203321Spacetime191321UNINA