05244nam 2200661 a 450 991080870050332120240313143542.01-118-53142-61-118-53135-3(CKB)2670000000335714(EBL)1124315(OCoLC)818327394(SSID)ssj0000831951(PQKBManifestationID)11966397(PQKBTitleCode)TC0000831951(PQKBWorkID)10880947(PQKB)10236415(MiAaPQ)EBC1124315(Au-PeEL)EBL1124315(CaPaEBR)ebr10658471(CaONFJC)MIL527811(PPN)221582843(EXLCZ)99267000000033571420121114d2013 uy 0engur|n|---|||||txtccrLysophospholipid receptors signaling and biochemistry /edited by Jerold Chun ... [et al.]1st ed.Hoboken, N.J. Wileyc20131 online resource (813 p.)Description based upon print version of record.0-470-56905-0 Includes bibliographical references and index.Cover; Title page; Copyright page; Contents; Preface; Contributors; CHAPTER 1: Lysophosphatidic Acid (LPA) Receptor Signaling; 1.1. Introduction; 1.2. LPA Metabolism; 1.3. Autotaxin; 1.4. LPA Receptors; 1.4.1. LPA1; 1.4.2. LPA2; 1.4.3. LPA3; 1.4.4. LPA4; 1.4.5. LPA5; 1.4.6. LPA6; 1.5. LPA Receptor Agonists and Antagonists; References; CHAPTER 2: Sphingosine 1-Phosphate (S1P) Receptors; 2.1. Introduction; 2.2. S1P Metabolism/Enzyme, and Transport; 2.2.1. S1P Metabolism and Enzymes; 2.2.2. Sphingosine Kinases; 2.2.3. S1P Phosphatases and S1P Lyase2.3. S1P Receptor Subtypes, and Physiological Functions2.3.1. S1P1; 2.3.2. S1P2; 2.3.3. S1P3; 2.3.4. S1P4; 2.3.5. S1P5; 2.4. Concluding Remarks; References; CHAPTER 3: Global Gene Expression Program of Lysophosphatidic Acid (LPA)-Stimulated Fibroblasts; 3.1. Introduction; 3.2. The Global Transcriptional Response of MEFs to LPA; 3.3. Upregulated Genes; 3.4. Downregulated Genes; 3.5. Induction of Genes that Encode Secreted Factors; 3.6. Overlap between the Expression Profiles of LPA and EGF; 3.7. Conclusions; Acknowledgments; ReferencesCHAPTER 4: Identification of Direct Intracellular Targets of Sphingosine 1-Phosphate (S1P)4.1. Introduction; 4.2. Intracellular Targets for S1P; 4.3. Methods to Identify Intracellular S1P Targets; 4.3.1. S1P Immobilized on Agarose Beads; 4.3.2. Binding of 32P-Labeled S1P to Targets; 4.3.3. Mass Measurement of Endogenous S1P in Immunoprecipitates of Target Proteins; 4.4. Other Potentially Useful Methods to Identify Lipid Binding Proteins; 4.4.1. Lipid Strips for Identification of Binding Proteins (Protein-Lipid Overlay)4.4.2. Detection of Lipid Binding Proteins by Enzyme-Linked Immunadsorbent Assays4.4.3. Liposome Pull Down; 4.5. Concluding Remarks; Acknowledgments; References; CHAPTER 5: Lysophospholipid Receptor Signaling Platforms: The Receptor Tyrosine Kinase-G Protein-Coupled Receptor Signaling Complex; 5.1. Introduction; 5.2. Lysophospholipid Receptor-Receptor Tyrosine Kinase Complexes; 5.3. Other Lysophospholipid Receptor Signaling Platforms; 5.4. Other Examples of RTK-GPCR Signaling Platforms5.5. Interaction of RGS Proteins with Receptor Tyrosine Kinase-Lysophospholipid Receptor Signaling Complexes5.6. S1P and RTK Transactivation; 5.7. Approaches for the Study of Receptor Tyrosine Kinase-Lysophospholipid Receptor Signaling Complexes; 5.8. Some Useful Protocols for Studying RTK-Lysophospholipid Receptor Signaling Platforms; 5.8.1. Compounds; 5.8.2. Cells; 5.8.3. Immunoprecipitation; 5.8.4. Immunofluorescence; 5.8.5. GTP-γ-S Binding Assay; 5.8.6. Cell Migration; 5.9. Conclusion; Acknowledgment; ReferencesCHAPTER 6: Autotaxin: A Unique Ecto-Type Pyrophosphodiesterase with Diverse Functions"This state-of-the-art reference addresses lysophospholipids, a special kind of fat that has been found to have a growing number of receptors within the cell and that has important, natural roles in the body, being essential for normal reproduction, development, maturation and life. This book covers the biochemistry, interactions, and signaling of lysophospholipids as well as its potential for producing new therapies for a range of medically important human diseases. Bringing together current knowledge in lysophospholipid signaling, this represents a must-have book for all academic, industrial, and medical school and hospital libraries"--Provided by publisher.Cell receptorsPhysiologyCell receptorsMetabolismCellular signal transductionPhysiologyCell receptorsPhysiology.Cell receptorsMetabolism.Cellular signal transductionPhysiology.571.7/4Chun Jerold1959-1614908MiAaPQMiAaPQMiAaPQBOOK9910808700503321Lysophospholipid receptors3944899UNINA06003nam 22005775 450 991025533760332120251116161556.03-319-44206-610.1007/978-3-319-44206-8(CKB)3710000000869899(DE-He213)978-3-319-44206-8(MiAaPQ)EBC4694502(EXLCZ)99371000000086989920160921d2016 u| 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierAnimal Ethics in the Age of Humans Blurring boundaries in human-animal relationships /edited by Bernice Bovenkerk, Jozef Keulartz1st ed. 2016.Cham :Springer International Publishing :Imprint: Springer,2016.1 online resource (XVII, 414 p. 5 illus.) The International Library of Environmental, Agricultural and Food Ethics,1570-3010 ;233-319-44205-8 Includes bibliographical references at the end of each chapters and index.Introduction -- Jozef Keulartz & Bernice Bovenkerk; Changing relationships with non-human animals in the Anthropocene -- Part 1. Between human and animal -- 1. Anita Guerrini; Deep history, evolutionary history, and animals in the Anthropocene -- 2. Sanne van der Hout; Organisms as teachers? The promise of biomimicry -- 3. Eva Meijer; Interspecies democracies -- 4. Michiel Korthals; Human-animal interfaces from a pragmatist perspective -- 5. Simon Burton & Emily Brady; What is it like to be a bird? Epistemic Humility and Human-Animal Relations -- 6. Jeffrey Moussaieff Masson and Susan McCarthy: Unfeeling Brutes -- 7. Comments: Henk van den Belt; Between human and animal -- Part 2. Between wild and domestic -- 8. Clare Palmer; Climate change, ethics, and the wildness of wild animals -- 9. Bernice Bovenkerk; Animal captivity: justifications for animal Captivity in the context of domestication -- 10. Jac. A.A. Swart; care for the wild in the Anthropocene -- 11. Martin Drenthen; The wolf and the animal lover.-12. Susan Boonman; Blurred boundaries in wildlife management practices -- 13. Comments: Sue Donaldson & Will Kymlicka; Between wildness and domestication: Rethinking categories and boundaries in response to animal agency -- Part 3. Between freedom and captivity -- 14. Jozef Keulartz; Towards an animal ethics for the Anthropocene -- 15. Aaron Simmons; Animals, freedom, and the ethics of veganism -- 16. T.J. Kasperbauer; Should captive primates have reproductive rights? -- 17. Sabrina Brando; Wild animals in entertainment -- 18. Comments: Clemens Driessen -- Part 4. Between animal ethics and conservation ethics -- 19. Jozef Keulartz; Captivity for conservation? Zoos at a Crossroads (reprint) -- 20. Brendon Larson & Stephanie Barr; The flights of the monarch butterfly: Between in situ and ex situ conservation -- 21. Bernice Bovenkerk & Marcel Verwey; Blurring the Boundaries Between Individualistic Animal Ethics and Holistic Environmental Ethics -- 22. Daniel Ramp & Marc Bekoff; Compassion as a practical and evolved ethic for conservation (reprint) -- 23. Comments: Hub Zwart; We all live in a planetary Ark (planetary Ark, planetary Ark….).This book provides reflection on the increasingly blurry boundaries that characterize the human-animal relationship. In the Anthropocene humans and animals have come closer together and this asks for rethinking old divisions. Firstly, new scientific insights and technological advances lead to a blurring of the boundaries between animals and humans. Secondly, our increasing influence on nature leads to a rethinking of the old distinction between individual animal ethics and collectivist environmental ethics. Thirdly, ongoing urbanization and destruction of animal habitats leads to a blurring between the categories of wild and domesticated animals. Finally, globalization and global climate change have led to the fragmentation of natural habitats, blurring the old distinction between in situ and ex situ conservation. In this book, researchers at the cutting edge of their fields systematically examine the broad field of human-animal relations, dealing with wild, liminal, and domestic animals, with conservation, and zoos, and with technologies such as biomimicry. This book is timely in that it explores the new directions in which our thinking about the human-animal relationship are developing. While the target audience primarily consists of animal studies scholars, coming from a wide range of disciplines including philosophy, sociology, psychology, ethology, literature, and film studies, many of the topics that are discussed have relevance beyond a purely theoretical one; as such the book also aims to inspire for example biologists, conservationists, and zoo keepers to reflect on their relationship with animals.The International Library of Environmental, Agricultural and Food Ethics,1570-3010 ;23Philosophy of natureEcologyZoologyPhilosophy of Naturehttps://scigraph.springernature.com/ontologies/product-market-codes/E34040Environment, generalhttps://scigraph.springernature.com/ontologies/product-market-codes/U00009Zoologyhttps://scigraph.springernature.com/ontologies/product-market-codes/L25007Philosophy of nature.Ecology.Zoology.Philosophy of Nature.Environment, general.Zoology.361.25Bovenkerk Berniceedthttp://id.loc.gov/vocabulary/relators/edtKeulartz Jozefedthttp://id.loc.gov/vocabulary/relators/edtMiAaPQMiAaPQMiAaPQBOOK9910255337603321Animal Ethics in the Age of Humans2518852UNINA