05742nam 2201909z- 450 991057687430332120220621(CKB)5720000000008432(oapen)https://directory.doabooks.org/handle/20.500.12854/84569(oapen)doab84569(EXLCZ)99572000000000843220202206d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierAnticancer Drugs 2021BaselMDPI - Multidisciplinary Digital Publishing Institute20221 online resource (594 p.)3-0365-4348-1 3-0365-4347-3 The Special Issue "Anticancer Drugs 2021" of Pharmaceuticals is focused on recent significant advances in the design, synthesis, molecular mechanism of action and therapeutic applications of anticancer drugs. This collection of preclinical research papers and reviews includes designed chemotherapeutic agents, targeted therapies and biological agents. The rationalization for the biological activity of these drugs is presented, which helps to guide the design of more effective agents. Structure-activity relationships, together with the biological context in which targets are selected for oncology drug development, are also considered.ChemistrybicsscResearch & information: generalbicssc1,2,3-triazole1,3,4-oxadiazole3-amino-4'-guanidino3,4'-bis-guanidino5-fluoruracil7-deaza-4'-thioadenosine derivativesacetamideadamantaneADC (antibody-drug conjugate)agealkylatedanticanceranticancer activityanticancer agentsapoptosisapoptosis inductionaromatase inhibitorBcl-2 inhibitorsbenzenesulfonamidesbenzimidazoleBRAFbreast cancercancercancer cell viabilitycancer vaccineCAR (chimeric antigen receptor)cardiotoxicitycarvedilolcell cycle analysischalconechalconescolony formationcombretastatin A-4concentration-guided dosingcovalent bindingCovDockcumulative dosecyclophosphamidecytotoxic activitycytotoxic agentscytotoxicitydesigned multiple liganddiphenyl etherDNA fragmentationdockingdoxazosindrug effluxdual inhibitorsdual-targeting moleculeEGFRELISAenantioselective synthesisentrectinibexportin-1gastric adenocarcinomageneric productH1299HDAC inhibitorsHER2heterocyclic compoundhistopathologyHL-60HT-29 cellshybrid compoundshybrid moleculehydrazide derivativesimidazolesImiquimodimmunotherapyin vitroin vivoindazoleIndole-based analoguesinflammationinterleukin-6intramolecular hydrogen bondisolationkidneylarotrectinibletrozoleMD simulationsMDA-MB-231 cellsmechanism predictionmiR-21mitoxantronemodel informed dosingMTT cytotoxic assayMUC1MUC16mucinmulti-kinase inhibitormultidrug resistancen/aNaMSAnitrogen scaffoldsNTRKnucleosideoxidative stresspatent reviewpemetrexedphenstatinphenyl pyridyl etherphysiologically based pharmacokineticsprotein kinase inhibitorsresin acidsolid/lipid nanoparticlessorafenibSTAT inhibitorssynthesisTDP1testisthieno[2,3-d][1,2,3]triazinethioureathymidylate synthasetissue-agnosticToll-Like ReceptortoxicityTrkTrk fusiontrypan blue assaytryptophanoltubulin polymerisation inhibitortumor spheroidstyrosil-DNA-phosphodiesterase 1urinary bladderUSFDAxanthoneChemistryResearch & information: generalMeegan Mary Jedt1325230O'Boyle Niamh MedtMeegan Mary JothO'Boyle Niamh MothBOOK9910576874303321Anticancer Drugs 20213036711UNINA05013nam 22005655 450 991025476020332120200630233516.09781484221310148422131110.1007/978-1-4842-2131-0(CKB)3710000000829366(DE-He213)978-1-4842-2131-0(MiAaPQ)EBC4644409(CaSebORM)9781484221310(PPN)19480741X(OCoLC)958874737(OCoLC)ocn958874737(EXLCZ)99371000000082936620160812d2016 u| 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierVFX Fundamentals Visual Special Effects Using Fusion 8.0 /by Wallace Jackson1st ed. 2016.Berkeley, CA :Apress :Imprint: Apress,2016.1 online resource (XXIV, 322 p. 250 illus. in color.) Includes index.Place of publication from publisher's website (viewed September 19, 2016).9781484221303 1484221303 Chapter 1: Visual Effects: Setup Your VFX Content Workstation -- Chapter 2: The Foundation of Raster for VFX: Pixels, Color and Alpha -- Chapter 3: The Foundation of Motion for VFX: Frames and Codecs -- Chapter 4: The Foundation of Audio for VFX: MIDI, Wave and Sample -- Chapter 5: The Foundation of 2D Vector for VFX: Point, Path and SVG -- Chapter 6: The Foundation of 3D Vector for VFX: Models and OpenGL -- Chapter 7: Professional VFX Software: Blackmagic Design Fusion -- Chapter 8: VFX Pipeline Composition: Using the Flow Node Editor -- Chapter 9: VFX Pipeline Animation: Using the Timeline Editor -- Chapter 10: VFX Pipeline Motion Control: Using the Spline Editor -- Chapter 11: VFX Pipeline Pixel Isolation: Using Animated Polyline Masking -- Chapter 12: VFX Pipeline Automated Masking: Matte Generators -- Chapter 13: VFX Pipeline Pixel Tracking: Using Motion Tracking -- Chapter 14: VFX Pipeline 3D Production: Compositing 3D Assets -- Chapter 15: VFX Pipeline 3D Rendering: Shader, Material and Texture -- Chapter 16: VFX Pipeline 3D Modeling: 3D Text Title Creation -- Chapter 17: VFX Pipeline 3D Animation: 3D Text Titling Modifiers -- Chapter 18: Advanced VFX Pipeline Effects: 3D Particle Systems -- Chapter 19: Advanced VFX Pipeline Physics: 3D Particle Physics -- Chapter 20: Advanced Interactive VFX: i3D Content Publishing -- .Learn concepts central to visual special effects using the free Blackmagic Design Fusion 8 software package. You'll discover foundational background information on concepts central to digital image compositing, digital video editing, digital illustration, digital painting, 3D, and digital audio. VFX Fundamentals builds on the foundational concepts of digital image compositing, digital audio, digital video, digital illustration and digital painting, and therefore expands on the other new media fundamentals titles in the New Media Fundamentals series, written by Wallace Jackson. VFX Fundamentals builds on the foundational concepts of digital image compositing, digital audio, digital video, digital illustration and digital painting, and therefore expands on the other new media fundamentals titles in the New Media Fundamentals Series, written by Wallace Jackson. VFX Fundamentals covers topics such as flow node compositing, timeline animation, animated polyline masking, bluescreen and greenscreen matte pulling (generation), using Primatte and Fusion 8 ultra keyer, motion tracking, 3D rendering and compositing, auxiliary channels, and particle systems and particle physics dynamics, among other topics. You will learn: The new media components (raster, vector, audio, video, rendering) needed for VFX The concepts behind the digital VFX content production workflow How to install and utilize Blackmagic Design Fusion 8 and its visual programming language Concepts behind resolution, aspect ratio, bit-rate, color depth, layers, alpha, and masking 2D VFX concepts such as animated masking, matte pulling (Primatte V) and motion tracking 3D VFX concepts such as 3D geometry, materials, lighting, animation, and auxiliary channels Advanced VFX concepts such as particle systems animation using real-world physics .Computer graphicsMultimedia systemsComputer Graphicshttps://scigraph.springernature.com/ontologies/product-market-codes/I22013Media Designhttps://scigraph.springernature.com/ontologies/product-market-codes/I25004Computer graphics.Multimedia systems.Computer Graphics.Media Design.006.6Jackson Wallaceauthttp://id.loc.gov/vocabulary/relators/aut709868UMIUMIBOOK9910254760203321VFX Fundamentals2283967UNINA