03076nam 22005295 450 991025465100332120200705070820.03-319-56210-X10.1007/978-3-319-56210-0(CKB)3710000001404663(DE-He213)978-3-319-56210-0(MiAaPQ)EBC4876545(PPN)202993728(EXLCZ)99371000000140466320170612d2017 u| 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierStroke Genetics /edited by Pankaj Sharma, James F. Meschia2nd ed. 2017.Cham :Springer International Publishing :Imprint: Springer,2017.1 online resource (XII, 431 p. 39 illus., 26 illus. in color.) 3-319-56208-8 Includes bibliographical references at the end of each chapters and index.Introduction -- Familial stroke epidemiology -- Association study results -- GWAS -- Aneurysms/carvernous/AVM -- ICH/amyloid/microbleeds -- CADASIL -- Fabry -- MELAS -- Sickle -- Other monogenic -- White matter disease -- Carotid atherosclerosis -- Dissection -- Pharmacogenomics -- Non-Caucasian stroke genetics -- Small vessel disease -- Genetics of neuroimaging in stroke -- Cerebrovenous thrombosis -- Ethics.This revised, expanded second edition updates the reader on this fast moving field as well providing an overall understanding of the genetics of complex diseases by using stroke as a paradigm. The reader will gain a comprehensive understanding of cerebrovascular genetics including the epidemiological evidence for the genetic basis of ischemic and hemorrhagic stroke, knowledge of its molecular basis from association, linkage and recent genomewide studies, and also monogenic disorders. Finally, the legal and ethical complexities in dealing with these issues are discussed. Stroke Genetics is a valuable resource for neurologists, stroke physicians, hypertension specialists, internists, clinical pharmacologists and those in training, as well as researchers in the field of disease genetics.Neurology Internal medicineHuman geneticsNeurologyhttps://scigraph.springernature.com/ontologies/product-market-codes/H36001Internal Medicinehttps://scigraph.springernature.com/ontologies/product-market-codes/H33002Human Geneticshttps://scigraph.springernature.com/ontologies/product-market-codes/B12008Neurology .Internal medicine.Human genetics.Neurology.Internal Medicine.Human Genetics.616.8Sharma Pankajedthttp://id.loc.gov/vocabulary/relators/edtMeschia James Fedthttp://id.loc.gov/vocabulary/relators/edtBOOK9910254651003321Stroke Genetics1758813UNINA