03951nam 22005535 450 991025452870332120200704105044.03-319-32337-710.1007/978-3-319-32337-4(CKB)3710000000829578(DE-He213)978-3-319-32337-4(MiAaPQ)EBC4643671(PPN)194801063(EXLCZ)99371000000082957820160811d2016 u| 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierNon-Neuronal Mechanisms of Brain Damage and Repair After Stroke /edited by Jun Chen, John H. Zhang, Xiaoming Hu1st ed. 2016.Cham :Springer International Publishing :Imprint: Springer,2016.1 online resource (XIII, 408 p. 49 illus., 44 illus. in color.) Springer Series in Translational Stroke Research,2363-958X3-319-32335-0 Includes bibliographical references at the end of each chapters.Part 1. Microvascular integrity in stroke -- 1. Structural alterations to the endothelial tight junction complex during stroke -- 2. Role of pericytes in neurovascular unite and stroke -- 3. Glial support of blood-brain barrier integrity: Molecular targets for novel therapeutic strategies in stroke -- 4. Barrier mechanism in neonatal stroke -- 5. Angiogenesis: a realistic therapy for ischemic stroke -- Part 2. Glial cells in stroke -- 6. Astrocytes as a target for ischemic stroke -- 7. Microglia: a double-sided sword in stroke -- 8. Crosstalk between cerebral endothelium and oligodendrocyte after stroke -- Part 3. Peripheral immune cells in stroke -- 9. The peripheral immune response to stroke -- 10. The Role of spleen-derived immune cells in ischemic brain injury -- 11. Regulatory T cells in ischemic brain injury -- 12. B cells in stroke and preconditioning-induced protection against stroke -- 13. Mast cell as an early responder in ischemic brain injury -- 14. Roles of neutrophils in stroke -- 15. The function of cytokines in ischemic stroke -- Part 4. White matter injury and repair in stroke -- 16. Ischemic injury to white matter: an age-dependent process -- 17. Neurovascular repair after stroke -- 18. The role of non-neuronal Nrf2 pathway in ischemic stroke: damage control and potential tissue repair -- 19. Stem cell therapy for ischemic stroke.This book provides a comprehensive overview of the latest research in the role of non-neuronal cells - astrocytes, oligodendrocytes, endothelial cells, pericytes, microglia, and other immune cells in ischemic brain injury and long-term recovery. In these cases, neurodegeneration and brain repair are controlled in a sophisticated system, incorporating interactions between different cell types and cellular systems. Also explored are the therapeutic strategies that target non-neuronal responses after stroke and their translational potentials.Springer Series in Translational Stroke Research,2363-958XNeurosciencesNeurology Neuroscienceshttps://scigraph.springernature.com/ontologies/product-market-codes/B18006Neurologyhttps://scigraph.springernature.com/ontologies/product-market-codes/H36001Neurosciences.Neurology .Neurosciences.Neurology.616.81Chen Junedthttp://id.loc.gov/vocabulary/relators/edtZhang John Hedthttp://id.loc.gov/vocabulary/relators/edtHu Xiaomingedthttp://id.loc.gov/vocabulary/relators/edtMiAaPQMiAaPQMiAaPQBOOK9910254528703321Non-Neuronal Mechanisms of Brain Damage and Repair After Stroke2497437UNINA