03769nam 22005895 450 991025415880332120200705192256.03-319-41818-110.1007/978-3-319-41818-6(CKB)4340000000061672(DE-He213)978-3-319-41818-6(MiAaPQ)EBC4922004(PPN)203666437(EXLCZ)99434000000006167220170721d2017 u| 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierProtein Therapeutics /edited by Zuben E. Sauna, Chava Kimchi-Sarfaty1st ed. 2017.Cham :Springer International Publishing :Imprint: Springer,2017.1 online resource (XIII, 182 p.) Topics in Medicinal Chemistry,1862-2461 ;213-319-41816-5 Includes bibliographical references at the end of each chapters and index.Protein Production in Eukaryotic Cells -- Production of Protein Therapeutics in the Quality by Design (QbD) Paradigm -- Characterization of Therapeutic Proteins -- Immunogenicity Lessons Learned from the Clinical Development of Vatreptacog Alfa, A Recombinant Activated Factor VII Analog, in Hemophilia with Inhibitors -- The Art of Gene Redesign and Recombinant Protein Production: Approaches and Perspectives.Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.Topics in Medicinal Chemistry,1862-2461 ;21Medicinal chemistryBiomedical engineeringProteins Medicinal Chemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/C28000Biomedical Engineering and Bioengineeringhttps://scigraph.springernature.com/ontologies/product-market-codes/T2700XProtein Sciencehttps://scigraph.springernature.com/ontologies/product-market-codes/L14040Medicinal chemistry.Biomedical engineering.Proteins .Medicinal Chemistry.Biomedical Engineering and Bioengineering.Protein Science.615.19Sauna Zuben Eedthttp://id.loc.gov/vocabulary/relators/edtKimchi-Sarfaty Chavaedthttp://id.loc.gov/vocabulary/relators/edtMiAaPQMiAaPQMiAaPQBOOK9910254158803321Protein Therapeutics1561706UNINA