01357nam--2200373---450-99000226601020331620091109104757.0000226601USA01000226601(ALEPH)000226601USA0100022660120041213h1983----km-y0itay0103----bagerDEa|||||||001yy<<Das>> GATT und die Entwicklungsländerdie Handelsprobleme der Dritten Welt und ihre blockierte LösungElmar Müllermit einem Vorwort von Hermann SautterFrankfurt am Main [etc.]Langcopyr. 1983118 p.ill.21 cmEuropäische HochschulschriftenReihe 5, Volks- und Betriebswirtschaft4732001Europäische HochschulschriftenReihe 5, Volks- und Betriebswirtschaft4732001001-------2001Paesi in via di sviluppoCommercio internazionale382MÜLLER,Elmar506066ITsalbcISBD990002266010203316XXIII.2.C. 147 (IG VIII 16 713)8943 E.C.XXIII.2.C. 147 (IG VIII 16)00246699BKGIUSIAV21020041213USA011856RSIAV59020091109USA011047GATT und die Entwicklungsländer785116UNISA07598nam 2200625 450 991048303650332120230717144513.03-030-68844-5(CKB)4100000011807239(MiAaPQ)EBC6531816(Au-PeEL)EBL6531816(OCoLC)1244626604(PPN)254726690(EXLCZ)99410000001180723920211019d2021 uy 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierNon-coding RNAs at the cross-road of cardiometabolic diseases and cancer /Paul HolvoetCham, Switzerland :Springer,[2021]©20211 online resource (xxx, 265 pages) illustrations3-030-68843-7 Includes bibliographical references.Intro -- Preface -- Acknowledgments -- Introduction -- The Move Towards Cellular Risk Markers -- Why Non-coding RNA? -- Objectives -- Approach -- Take Home Message -- References -- Contents -- Abbreviations -- 1 Biogenesis and Modes of Action of miRs and Circular and Long Non-coding RNAs -- 1.1 MiRs -- 1.1.1 Biogenesis of miRs -- 1.1.2 MiR Modes of Action -- 1.1.3 Naming of miRs -- 1.1.4 Useful Resources on miRs -- 1.2 Circular RNAs -- 1.2.1 Biogenesis of Circular RNAs -- 1.2.2 Circular RNAs Modes of Action -- 1.2.3 Useful Resources on Circ-RNAs -- 1.3 lncRNAs -- 1.3.1 Biogenesis of lncRNAs -- 1.3.2 Modes of Action of lncRNAs -- 1.4 piRs -- 1.4.1 Biogenesis of piRs -- 1.4.2 Modes of Action of piRs -- 1.4.3 Useful Resources on piRs -- References -- 2 Non-coding RNAs Related to Obesity -- 2.1 Mechanisms in White Adipogenesis -- 2.1.1 Role of Non-coding RNAs in White Adipogenesis -- 2.2 Inflammation and Insulin Resistance in Obese White Adipose Tissue -- 2.2.1 Role of Non-coding RNAs in Inflammation and Insulin Resistance in Obese White Adipose Tissue -- 2.3 Mechanisms in Brown Adipogenesis and Thermogenesis -- 2.3.1 Role of Non-coding RNAs in Brown Adipogenesis and Thermogenesis -- 2.4 Mechanisms in Browning of White Adipose Tissues -- 2.4.1 Role of Non-coding RNAs in Browning of White Adipose Tissue -- 2.5 Leptin and Insulin in the Hypothalamus -- 2.5.1 Non-coding RNAs Related to Leptin and Insulin in the Hypothalamus -- References -- 3 Non-coding RNAS Related to Type 2 Diabetes -- 3.1 Mechanisms in β Cell Maturation -- 3.1.1 Non-coding RNAs Related to β Cell Maturation -- 3.2 Mechanisms in Insulin Signaling in the Pancreas -- 3.2.1 Non-coding RNAs in Insulin Signaling in Type 2 Diabetes -- 3.3 Inflammation in the Pancreas, Insulin Resistance, and Type 2 Diabetes.3.3.1 Non-coding RNAs Related to Inflammation in the Pancreas, with Insulin Resistance and Type 2 Diabetes -- References -- 4 Non-coding RNAs Related to Lipid Metabolism and Non-alcoholic Fatty Liver Disease -- 4.1 Cholesterol and Lipids in the Liver -- 4.1.1 Non-coding RNAs and Cholesterol in the Liver -- 4.2 Fatty Acids and Triglycerides -- 4.2.1 Non-coding RNAs and Fatty Acids and Triglycerides -- 4.3 Non-alcoholic Fatty Liver Disease -- 4.3.1 Non-coding RNAs Related to Non-alcoholic Fatty Liver Disease -- References -- 5 Non-coding RNAs Related to Atherosclerosis -- 5.1 Endothelial Injury, Inflammation, and Apoptosis -- 5.1.1 Non-coding RNAs in Endothelial Injury, Inflammation, and Apoptosis -- 5.2 Fibroproliferative Remodeling and Plaque Destabilization -- 5.2.1 Non-coding RNAs in Fibroproliferative Remodeling and Plaque Destabilization -- References -- 6 Non-coding RNAs in Cardiomyopathy and Heart Failure -- 6.1 Mechanisms in Cardiomyopathy and Heart Failure -- 6.2 Non-coding RNAs in Cardiomyopathy and Heart Failure -- 6.2.1 Non-coding RNAs in Cardiac Hypertrophy -- 6.2.2 Non-coding RNAs in Cardiac Fibrosis and ECM Deposition -- 6.2.3 Non-coding RNAs in Cardiac Inflammation -- 6.2.4 Non-coding RNAs in Cardiac Angiogenesis -- 6.2.5 Non-coding RNAs in Cardiac Apoptosis -- 6.3 Metabolic Syndrome: The Link Between Metabolic and Cardiovascular Diseases -- 6.3.1 Definition of Metabolic Syndrome -- 6.3.2 Oxidative Stress and Metabolic Syndrome -- 6.3.3 Metabolic Syndrome and Cardiovascular Risk -- 6.3.4 Non-coding RNAs and Metabolic Syndrome Components -- References -- 7 Non-coding RNAs Related to Cardiometabolic Diseases and Associated to Cancer -- 7.1 Mechanisms of Cancer Progression -- 7.1.1 Induction of Stemness -- 7.1.2 Induction of EMT -- 7.1.3 Induction of Insulin Sensitized State, Cancer Cell Proliferation, and Protection Against Apoptosis.7.1.4 Induction of Glycolysis -- 7.1.5 Induction of Angiogenesis -- 7.1.6 Repression of Anti-tumor Immunity and Apoptosis -- 7.1.7 Cancer Cell Proliferation -- 7.1.8 EGFR Signaling and Cancer Progression -- 7.1.9 BMI1 and EZH2 in Cancer Progression -- 7.2 Non-coding RNAs Related to Metabolic and Cardiovascular Diseases Are also Involved in Cancer Progression -- 7.3 Comparison of the Role of Non-coding RNAs in Cardiometabolic Diseases and Cancer -- References -- 8 Regulation of Non-coding RNAs in Cardiometabolic Tissues and Tumors -- 8.1 Regulation of miRs -- 8.1.1 Hypoxia -- 8.1.2 Glucose -- 8.1.3 Oxidative Stress -- 8.1.4 Inflammation -- 8.1.5 TGF-β -- 8.1.6 MYC -- 8.1.7 Overview -- 8.2 Differences in miR-Profiles in Cardiometabolic Tissues and Tumors May be Due to the Typical Action of lncRNAs and circ-RNAs in Tumors -- 8.3 Action of piRs Particularly in Tumors -- References -- 9 Communication Between Tumor-Adjacent Tissues and Tumors with Emphasis on Role of Inflammatory Cells -- 9.1 Exchange of miR-Enriched Microvesicles -- 9.2 MiR-155 as a Link Between M1 Macrophage-Mediated Inflammation in Tumor-Adjacent Tissue and Tumor Growth and Metastasis -- References -- 10 The Impact of Non-coding RNA Networks on Disease Comorbidity: Cardiometabolic Diseases, Inflammatory Diseases, and Cancer -- 10.1 Identification of Non-coding RNAs at Cross-Road of Metabolic and Cardiovascular Diseases -- 10.2 Many Non-coding RNAs at Cross-Road of Metabolic and Cardiovascular Diseases are also Related to Inflammatory Diseases -- 10.3 Differences Between Non-coding RNAs in Cardiometabolic Tissues and Tumors -- 10.4 Expected Technical Developments Underlying the Use of Non-coding RNAs as Biomarkers -- 10.5 The Need for Measuring Fluctuation of Non-coding RNAs -- References.Non-coding RNACardiovascular systemDiseasesMolecular aspectsMetabolismDisordersMolecular aspectsCancerGenetic aspectsCàncerthubMalalties cardiovascularsthubTrastorns del metabolismethubGenètica molecular humanathubLlibres electrònicsthubNon-coding RNA.Cardiovascular systemDiseasesMolecular aspects.MetabolismDisordersMolecular aspects.CancerGenetic aspects.CàncerMalalties cardiovascularsTrastorns del metabolismeGenètica molecular humana572.88Holvoet Paul851128MiAaPQMiAaPQMiAaPQBOOK9910483036503321Non-coding RNAs at the cross-road of cardiometabolic diseases and cancer1900325UNINA05291nam 22008175 450 991025406420332120200701213450.03-319-27836-310.1007/978-3-319-27836-0(CKB)3710000000765121(DE-He213)978-3-319-27836-0(MiAaPQ)EBC6315118(MiAaPQ)EBC5578816(Au-PeEL)EBL5578816(OCoLC)953828379(PPN)194516431(EXLCZ)99371000000076512120160714d2016 u| 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierMathematical Modelling /by Matti Heiliö, Timo Lähivaara, Erkki Laitinen, Timo Mantere, Jorma Merikoski, Seppo Pohjolainen, Kimmo Raivio, Risto Silvennoinen, Antti Suutala, Tanja Tarvainen, Timo Tiihonen, Jukka Tuomela, Esko Turunen, Marko Vauhkonen ; edited by Seppo Pohjolainen1st ed. 2016.Cham :Springer International Publishing :Imprint: Springer,2016.1 online resource (XI, 242 p. 56 illus., 13 illus. in color.) 3-319-27834-7 1 Introduction by S. Pohjolainen and M. Heiliö -- 2 Models and Applications by M. Heiliö -- 3 Viewpoints on Systems and Models by E. Laitinen -- 4 Integer Models by R. Silvennoinen and J. Merikoski -- 5 Data Based Models by J. Merikoski et al -- 6 Soft Computing Methods by E. Turunen et al -- 7 Dimensional Analysis by T. Tiihonen -- 8 Modelling With Differential Equations by J. Tuomela -- 9 Continuum Models by T. Tiihonen -- 10 Simplification of Models by T. Tiihonen -- 11 Acoustic Modelling by S. Pohjolainen and A. Suutala -- 12 Inverse Problems by M. Vauhkonen et al -- 13 Project Titles by M. Heiliö. .This book provides a thorough introduction to the challenge of applying mathematics in real-world scenarios. Modelling tasks rarely involve well-defined categories, and they often require multidisciplinary input from mathematics, physics, computer sciences, or engineering. In keeping with this spirit of modelling, the book includes a wealth of cross-references between the chapters and frequently points to the real-world context. The book combines classical approaches to modelling with novel areas such as soft computing methods, inverse problems, and model uncertainty. Attention is also paid to the interaction between models, data and the use of mathematical software. The reader will find a broad selection of theoretical tools for practicing industrial mathematics, including the analysis of continuum models, probabilistic and discrete phenomena, and asymptotic and sensitivity analysis. .Mathematical modelsApplied mathematicsEngineering mathematicsComputer scienceMathematicsComputer simulationMathematical Modeling and Industrial Mathematicshttps://scigraph.springernature.com/ontologies/product-market-codes/M14068Mathematical and Computational Engineeringhttps://scigraph.springernature.com/ontologies/product-market-codes/T11006Computational Science and Engineeringhttps://scigraph.springernature.com/ontologies/product-market-codes/M14026Simulation and Modelinghttps://scigraph.springernature.com/ontologies/product-market-codes/I19000Mathematical models.Applied mathematics.Engineering mathematics.Computer scienceMathematics.Computer simulation.Mathematical Modeling and Industrial Mathematics.Mathematical and Computational Engineering.Computational Science and Engineering.Simulation and Modeling.511.8Heiliö Mattiauthttp://id.loc.gov/vocabulary/relators/aut897054Lähivaara Timoauthttp://id.loc.gov/vocabulary/relators/autLaitinen Erkkiauthttp://id.loc.gov/vocabulary/relators/autMantere Timoauthttp://id.loc.gov/vocabulary/relators/autMerikoski Jormaauthttp://id.loc.gov/vocabulary/relators/autPohjolainen Seppoauthttp://id.loc.gov/vocabulary/relators/autRaivio Kimmoauthttp://id.loc.gov/vocabulary/relators/autSilvennoinen Ristoauthttp://id.loc.gov/vocabulary/relators/autSuutala Anttiauthttp://id.loc.gov/vocabulary/relators/autTarvainen Tanjaauthttp://id.loc.gov/vocabulary/relators/autTiihonen Timoauthttp://id.loc.gov/vocabulary/relators/autTuomela Jukkaauthttp://id.loc.gov/vocabulary/relators/autTurunen Eskoauthttp://id.loc.gov/vocabulary/relators/autVauhkonen Markoauthttp://id.loc.gov/vocabulary/relators/autPohjolainen Seppoedthttp://id.loc.gov/vocabulary/relators/edtMiAaPQMiAaPQMiAaPQBOOK9910254064203321Mathematical Modelling2004333UNINA