03405nam 22006255 450 991025406100332120230810213720.03-658-13234-510.1007/978-3-658-13234-7(CKB)3710000000616478(EBL)4454269(SSID)ssj0001653989(PQKBManifestationID)16433763(PQKBTitleCode)TC0001653989(PQKBWorkID)14982956(PQKB)11256628(DE-He213)978-3-658-13234-7(MiAaPQ)EBC4454269(PPN)192770985(EXLCZ)99371000000061647820160317d2016 u| 0engur|n|---|||||txtccrAnalysis of Single-Cell Data ODE Constrained Mixture Modeling and Approximate Bayesian Computation /by Carolin Loos1st ed. 2016.Wiesbaden :Springer Fachmedien Wiesbaden :Imprint: Springer Spektrum,2016.1 online resource (108 p.)BestMasters,2625-3615Description based upon print version of record.3-658-13233-7 Includes bibliographical references.Modeling and Parameter Estimation for Single-Cell Data -- ODE Constrained Mixture Modeling for Multivariate Data -- Approximate Bayesian Computation Using Multivariate Statistics.Carolin Loos introduces two novel approaches for the analysis of single-cell data. Both approaches can be used to study cellular heterogeneity and therefore advance a holistic understanding of biological processes. The first method, ODE constrained mixture modeling, enables the identification of subpopulation structures and sources of variability in single-cell snapshot data. The second method estimates parameters of single-cell time-lapse data using approximate Bayesian computation and is able to exploit the temporal cross-correlation of the data as well as lineage information. Contents Modeling and Parameter Estimation for Single-Cell Data ODE Constrained Mixture Modeling for Multivariate Data Approximate Bayesian Computation Using Multivariate Statistics Target Groups Researchers and students in the fields of (bio-)mathematics, statistics, bioinformatics System biologists, biostatisticians, bioinformaticians The Author Carolin Loos is currently doing her PhD at the Institute of Computational Biology at the Helmholtz Zentrum München. She is member of the junior research group „Data-driven Computational Modeling“.BestMasters,2625-3615BiomathematicsMathematicsData processingBioinformaticsMathematical and Computational BiologyComputational Mathematics and Numerical AnalysisComputational and Systems BiologyBiomathematics.MathematicsData processing.Bioinformatics.Mathematical and Computational Biology.Computational Mathematics and Numerical Analysis.Computational and Systems Biology.510Loos Carolinauthttp://id.loc.gov/vocabulary/relators/aut755825BOOK9910254061003321Analysis of single-cell data1523145UNINA