03304nam 22005895 450 991025402590332120200705061557.03-319-20040-210.1007/978-3-319-20040-8(CKB)3710000000711712(DE-He213)978-3-319-20040-8(MiAaPQ)EBC4533798(PPN)194074145(EXLCZ)99371000000071171220160527d2016 u| 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierComputational Modelling of the Human Islet Amyloid Polypeptide /by Katrine Kirkeby Skeby1st ed. 2016.Cham :Springer International Publishing :Imprint: Springer,2016.1 online resource (XVI, 118 p. 58 illus., 47 illus. in color.) Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5053"Doctoral thesis accepted by the Aarhus University, Aarhus C, Denmark."3-319-20039-9 Includes bibliographical references at the end of each chapters.Amyloid and Amyloid Fibrils -- Computational Theory -- Imaging Agent Binding to Amyloid Protofibrils -- Determining the Aggregation Prone Structure of hiAPP -- Effect of Terminal Capping on Aggregation of Peptide Fragments -- Coarse Grained Study of Amyloid Protofibril Aggregation -- Conclusion and Perspectives.This thesis offers readers a comprehensive introduction to amyloid proteins and the computational methods used with them. Katrine Skeby critically assesses and compares both the literature and the experiments performed by other researchers, which further elevates the quality and relevance of her own work. Amyloid proteins are highly complex, and this research provides unparalleled insights, especially with regard to the origin of cytotoxicity and to developing technologies for early detection, revealing in detail the molecular mechanisms behind hIAPP behavior. Several studies within the thesis answer difficult questions which promote future research into the properties of amyloid proteins.Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5053Pharmaceutical chemistryCheminformaticsBioorganic chemistryMedicinal Chemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/C28000Computer Applications in Chemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/C13009Bioorganic Chemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/C19010Pharmaceutical chemistry.Cheminformatics.Bioorganic chemistry.Medicinal Chemistry.Computer Applications in Chemistry.Bioorganic Chemistry.540Skeby Katrine Kirkebyauthttp://id.loc.gov/vocabulary/relators/aut1059821MiAaPQMiAaPQMiAaPQBOOK9910254025903321Computational Modelling of the Human Islet Amyloid Polypeptide2508528UNINA