02742nam 22004815 450 991025394690332120200704095932.03-319-70142-810.1007/978-3-319-70142-4(CKB)4100000001382021(DE-He213)978-3-319-70142-4(MiAaPQ)EBC5182420(PPN)222229233(EXLCZ)99410000000138202120171204d2017 u| 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierResistance to Targeted Therapies in Breast Cancer /edited by Jenifer R. Prosperi1st ed. 2017.Cham :Springer International Publishing :Imprint: Springer,2017.1 online resource (XV, 184 p. 12 illus. in color.) Resistance to Targeted Anti-Cancer Therapeutics,2196-5501 ;163-319-70141-X Includes bibliographical references at the end of each chapters and index.Invasive Breast Cancer Therapy 2017: How Well Are We Hitting The Target? -- Resistance to HER2-targeted therapy -- Endocrine Resistance and Breast Cancer Stem Cells – The Inflammatory Connection That Could Lead to New and Improved Therapy Outcomes -- EGFR Resistance -- Targeting FGFR for the treatment of breast cancer -- Targeted Therapies in Breast Cancer -- Future paradigm of breast cancer resistance and treatment.We present an in-depth description of resistance to targeted therapies in breast cancer. Targeted therapies discussed here include those used to treat ER+ or Her2+ breast cancers (i.e., Tamoxifen or trastuzumab) or those targeting signaling pathways aberrantly activated in triple negative breast cancer (i.e., EGFR and Wnt signaling). We have also provided an overview of standard of care as an introduction into the importance of targeted therapy. It is our hope that this volume gives an insight into the landscape of breast cancer treatment, the challenges of targeted therapy, and a glimpse into the future of breast cancer therapy.  .Resistance to Targeted Anti-Cancer Therapeutics,2196-5501 ;16Cancer researchCancer Researchhttps://scigraph.springernature.com/ontologies/product-market-codes/B11001Cancer research.Cancer Research.616.99449061Prosperi Jenifer Redthttp://id.loc.gov/vocabulary/relators/edtMiAaPQMiAaPQMiAaPQBOOK9910253946903321Resistance to Targeted Therapies in Breast Cancer2019300UNINA