03584nam 22005775 450 991025394640332120200710083104.03-319-64526-910.1007/978-3-319-64526-1(CKB)4100000000882319(DE-He213)978-3-319-64526-1(MiAaPQ)EBC5111847(PPN)220121982(EXLCZ)99410000000088231920171024d2017 u| 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierIgM and Its Receptors and Binding Proteins /edited by Hiromi Kubagawa, Peter D. Burrows1st ed. 2017.Cham :Springer International Publishing :Imprint: Springer,2017.1 online resource (IX, 117 p. 30 illus., 15 illus. in color.) Current Topics in Microbiology and Immunology,0070-217X ;408Includes bibliographical references.The appearance and diversification of receptors for IgM during vertebrate evolution. -- Authentic IgM Fc Receptor (FcμR) -- FCRLA - A resident endoplasmic reticulum protein that associates with multiple immunoglobulin isotypes in B lineage cells -- Specific IgM and regulation of antibody responses -- Role of Natural IgM autoantibodies (IgM- NAA) and IgM anti-leucocyte antibodies (IgM-ALA) in regulating inflammation.This volume reviews the current state of research on the IgM antibody and its multiple receptors and binding proteins. Interactions of the IgM ligands with these molecules are important for protection against infections as a first line of defense, as well as for regulation of immune responses to pathogens and self-antigens. The book includes up-to-date information on: (i) the phylogeny of three IgM-binding receptors [polymeric Ig receptor (pIgR), Fc receptor for both IgA and IgM (Fcα/µR), and Fc receptor for IgM only (FcµR)]; (ii) the lymphocyte-restricted distribution and unique ligand-binding activity of FcµR; (iii) the definition and potential function of Fc receptor-like molecule A (FCRLA) as a resident endoplasmic reticulum protein that binds IgM, but also IgG and IgA; (iv) IgM antibody-mediated enhancement of humoral immune responses, highlighting the importance of complement and its receptors, (v) the numerous important roles of IgM natural antibodies in regulation of inflammation. It is an invaluable resource for researchers and clinicians alike.Current Topics in Microbiology and Immunology,0070-217X ;408ImmunologyInfectious diseasesRheumatologyImmunologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B14000Infectious Diseaseshttps://scigraph.springernature.com/ontologies/product-market-codes/H33096Rheumatologyhttps://scigraph.springernature.com/ontologies/product-market-codes/H33170Immunology.Infectious diseases.Rheumatology.Immunology.Infectious Diseases.Rheumatology.616.9706Kubagawa Hiromiedthttp://id.loc.gov/vocabulary/relators/edtBurrows Peter Dedthttp://id.loc.gov/vocabulary/relators/edtMiAaPQMiAaPQMiAaPQBOOK9910253946403321IgM and Its Receptors and Binding Proteins1954759UNINA