01587nam 2200385 450 991080938980332120240112051747.09789275325780(electronic bk.)9789275125786(MiAaPQ)EBC30500498(Au-PeEL)EBL30500498(EXLCZ)992651177950004120240112d2022 uy 0spaurcnu||||||||txtrdacontentcrdamediacrrdacarrierHerramienta de Planificación y Presupuestación para Pruebas de Tuberculosis y Tuberculosis Farmacorresistente Guía Del Usuario /Pan American Health OrganizationFirst edition.Washington, D.C. :Organización Panamericana de la Salud,[2022]©20221 online resource (14 pages)Print version: Organization, Pan American Health Herramienta de Planificación y Presupuestación para Pruebas de Tuberculosis y Tuberculosis Farmacorresistente Bloomfield : Pan American Health Organization (PAHO),c2022 9789275125786 Business forecastingMethodologyBusiness forecastingComputer programsBusiness forecastingMethodology.Business forecastingComputer programs.330MiAaPQMiAaPQMiAaPQ9910809389803321Herramienta de Planificación y Presupuestación para Pruebas de Tuberculosis y Tuberculosis Farmacorresistente4008067UNINA04379nam 22007455 450 991025394070332120251116182917.03-319-63953-610.1007/978-3-319-63953-6(CKB)3710000001631550(MiAaPQ)EBC4978945(DE-He213)978-3-319-63953-6(PPN)203850955(EXLCZ)99371000000163155020170816d2017 u| 0engurcnu||||||||rdacontentrdamediardacarrierBiomedical Applications of Acridines Derivatives, Syntheses, Properties and Biological Activities with a Focus on Neurodegenerative Diseases /by Jan Ježek, Jan Hlaváček, Jaroslav Šebestík1st ed. 2017.Cham :Springer International Publishing :Imprint: Springer,2017.1 online resource (237 pages) illustrations (some color)Progress in Drug Research,0071-786X ;723-319-63952-8 Includes bibliographical references at the end of each chapters and index.Preliminary ToC 1 Introduction -- 2 Nomenclature -- 3. Syntheses -- 4. Interactions of acridines with nucleic acids -- 5. Intercations with proteins -- 6. Applications for treament of neurodegenerative diseases -- 7. Some applications of selective toxicities of acridines -- 8. Acridine on dendrimeric carriers -- 9 Acridines used for staining -- 10 Miscellaneous -- 11 Conclusions and outlook.This book describes applications of acridines for the treatment of various neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and various prion diseases, and discusses the potential of acridines in neuro-regenerative medicine. Using modern data-mining software, it presents structures of acridines with nucleic acids and proteins and compares them with the native structures. Furthermore, the book presents modern methods of acridine synthesis, comparing them with the most useful conventional methods. Acridines interact with both nucleic acids and proteins, and due to their direct interactions with various enzymes, they can be suitable for the treatment of neurodegenerative diseases, inflammation, immunological disorders, and protozoal diseases. The characteristic spectral properties of acridines can  be employed in labeling proteins, nucleic acids, lipids, and even cells and their compartments. Moreover, they can be applied in photodynamic therapy.Progress in Drug Research,0071-786X ;72Pharmaceutical chemistryNeurochemistryPharmacologyProteinsBioorganic chemistryNucleic acidsMedicinal Chemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/C28000Neurochemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/B18010Pharmacology/Toxicologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B21007Protein-Ligand Interactionshttps://scigraph.springernature.com/ontologies/product-market-codes/L14060Bioorganic Chemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/C19010Nucleic Acid Chemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/L14011Pharmaceutical chemistry.Neurochemistry.Pharmacology.Proteins.Bioorganic chemistry.Nucleic acids.Medicinal Chemistry.Neurochemistry.Pharmacology/Toxicology.Protein-Ligand Interactions.Bioorganic Chemistry.Nucleic Acid Chemistry.547.593Ježek Janauthttp://id.loc.gov/vocabulary/relators/aut0Hlaváček Janauthttp://id.loc.gov/vocabulary/relators/autŠebestík Jaroslavauthttp://id.loc.gov/vocabulary/relators/autMiAaPQMiAaPQMiAaPQBOOK9910253940703321Biomedical Applications of Acridines1954756UNINA